N-hexane

Names

[ CAS No. ]:
110-54-3

[ Name ]:
N-hexane

[Synonym ]:
n-Hexane,AcroSeal,Extra Dry
MFCD02179311
n-Hexane,ECD tested halocarbons free grade
n-Hexane,residue free
EINECS 203-777-6
Residual Solvent Class 2 - Hexane
N-hexane

Chemical & Physical Properties

[ Density]:
0.7±0.1 g/cm3

[ Boiling Point ]:
68.5±3.0 °C at 760 mmHg

[ Melting Point ]:
-95ºC

[ Molecular Formula ]:
C₆H₁₄

[ Molecular Weight ]:
86.175

[ Flash Point ]:
-23.3±0.0 °C

[ Exact Mass ]:
86.109550

[ LogP ]:
3.94

[ Vapour density ]:
3.5 (vs air)

[ Vapour Pressure ]:
150.9±0.1 mmHg at 25°C

[ Index of Refraction ]:
1.384

[ Stability ]:
Stable. Incompatible with oxidizing agents, chlorine, fluorine, magnesium perchlorate. Highly flammable. Readily forms explosive mixtures with air. Note low flash point.

[ Water Solubility ]:
insoluble

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MN9275000

CHEMICAL NAME :: Hexane

CAS REGISTRY NUMBER :: 110-54-3

LAST UPDATED :: 199712

DATA ITEMS CITED :: 61

MOLECULAR FORMULA :: C6-H14

MOLECULAR WEIGHT :: 86.20

WISWESSER LINE NOTATION :: 6H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human

DOSE/DURATION :: 190 ppm/8W

TOXIC EFFECTS :: Peripheral Nerve and Sensation - structural change in nerve or sheath

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 28710 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 48000 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 120 gm/m3

TOXIC EFFECTS :: Behavioral - general anesthetic Lungs, Thorax, or Respiration - respiratory depression Cardiac - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 831 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 132 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2000 ppm/12H/24W-I

TOXIC EFFECTS :: Spinal Cord - other degenerative changes Peripheral Nerve and Sensation - recording from peripheral motor nerve Biochemical - Metabolism (Intermediary) - other proteins

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 40 gm/kg/4W-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1000 ppm/24H/11W-C

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Behavioral - muscle weakness Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 pph/6H/13W-I

TOXIC EFFECTS :: Brain and Coverings - changes in brain weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 476 ppm/6H/4W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3000 ppm/6H/2Y-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 ppm/24H/9W-C

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18900 mg/kg/35D-I

TOXIC EFFECTS :: Peripheral Nerve and Sensation - recording from afferent nerve Peripheral Nerve and Sensation - recording from peripheral motor nerve Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4788 mg/kg/7D-I

TOXIC EFFECTS :: Liver - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1200 ppm/12H/16W-I

TOXIC EFFECTS :: Peripheral Nerve and Sensation - recording from peripheral motor nerve Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Metabolism (Intermediary) - other proteins

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10000 ppm/6H/13W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - changes in motor activity (specific assay) Blood - changes in other cell count (unspecified)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 18 gm/kg/90D-I

TOXIC EFFECTS :: Peripheral Nerve and Sensation - structural change in nerve or sheath Behavioral - ataxia Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 10000 ppm/7H

SEX/DURATION :: female 15 day(s) pre-mating female 1-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 1000 ppm/6H

SEX/DURATION :: female 8-16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 5000 ppm/20H

SEX/DURATION :: female 6-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 238 gm/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Fibroblast

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 22,623,1984 *** REVIEWS *** ACGIH TLV-TWA 176 mg/m3 (50 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 500 ppm (1800 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,126,1971 OSHA PEL (Gen Indu):8H TWA 500 ppm (1800 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 500 ppm (1800 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 500 ppm (1800 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 500 ppm (1800 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 50 ppm (180 mg/m3) JAN 1993 OEL-BELGIUM:TWA 50 ppm (176 mg/m3) JAN 1993 OEL-DENMARK:TWA 50 ppm (180 mg/m3) JAN 1993 OEL-FINLAND:TWA 50 ppm (180 mg/m3);STEL 150 ppm (530 mg/m3) JAN 1993 OEL-FRANCE:TWA 50 ppm (170 mg/m3) JAN 1993 OEL-GERMANY:TWA 50 ppm (180 mg/m3) JAN 1993 OEL-HUNGARY:TWA 100 mg/m3;STEL 200 mg/m3;Skin JAN 1993 OEL-JAPAN:TWA 40 ppm (140 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 100 ppm (360 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 500 ppm (1800 mg/m3) JAN 1993 OEL-POLAND:TWA 400 mg/m3 JAN 1993 OEL-RUSSIA:TWA 40 ppm;STEL 300 mg/m3 JAN 1993 OEL-SWEDEN:TWA 25 ppm (90 mg/m3);STEL 50 ppm (180 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 50 ppm (180 mg/m3);STEL 100 ppm (360 mg/m3) JAN 1993 OEL-TURKEY:TWA 500 ppm (1800 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 100 ppm (360 mg/m3);STEL 125 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO HEXANE-air:10H TWA 50 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 36955 No. of Facilities: 72257 (estimated) No. of Industries: 281 No. of Occupations: 168 No. of Employees: 763261 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 36955 No. of Facilities: 40256 (estimated) No. of Industries: 221 No. of Occupations: 161 No. of Employees: 643101 (estimated) No. of Female Employees: 138726 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS07, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H304-H315-H336-H361f-H373-H411

[ Precautionary Statements ]:
P201-P210-P273-P301 + P310-P308 + P313-P331

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F:Flammable

[ Risk Phrases ]:
R11;R38;R48/20;R51/53;R62;R65;R67

[ Safety Phrases ]:
S16-S29-S33-S36/37-S61-S62-S9

[ RIDADR ]:
UN 1208

[ WGK Germany ]:
3

[ RTECS ]:
MN9275000

[ Packaging Group ]:
II

[ Hazard Class ]:
3

[ HS Code ]:
2901100000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1-hexene
1-Hexanol
Carbon dioxide
Dichloromethane
Butylmagnesium chloride
1-Bromohexane
Methylcyclopentane
2-Hexanone
Hex-1-yne
4-Methoxybenzyl alcohol

DownStream

methylamine
(2E)-1,4-Dibromo-2-butene
3,4-Dibromo-1-butene
triisothiocyanato(methyl)silane
2-BROMOHEXANE
3-BROMOHEXANE
1-Bromohexane
N-HEXYLPHOSPHONIC ACID
Perfluorohexane
perfluoro-2-methylpentane

Customs

[ HS Code ]: 2901100000

[ Summary ]:
2901100000 saturated acyclic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

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N-HEXANES
n-hexane-d14
1-iodo-n-hexane
1-nitro-n-hexane
1-bromo-n-hexane
n-hexane-1,2-diol
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
N-[3-(Aminooxy)propyl]-N-butyl-1-butanamine