Diglycolic acid

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Names

[ CAS No. ]:
110-99-6

[ Name ]:
Diglycolic acid

[Synonym ]:
Diglycolic acid
oxydiacetic acid
2,2'-Oxydiacetic acid
2-(carboxymethoxy)acetic acid
MFCD00004309
EINECS 203-823-5
Acetic acid, 2,2'-oxybis-
oxodiethanoic acid

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
445.2±20.0 °C at 760 mmHg

[ Melting Point ]:
140-144 °C(lit.)

[ Molecular Formula ]:
C4H6O5

[ Molecular Weight ]:
134.087

[ Flash Point ]:
201.7±15.3 °C

[ Exact Mass ]:
134.021530

[ PSA ]:
83.83000

[ LogP ]:
-2.09

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.476

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AJ1530000
CHEMICAL NAME :
Acetic acid, oxydi-
CAS REGISTRY NUMBER :
110-99-6
BEILSTEIN REFERENCE NO. :
1072117
LAST UPDATED :
199710
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C4-H6-O5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ACIEAY Angewandte Chemie, International Edition in English. (VCH Pub., Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441) V.1- 1962- Volume(issue)/page/year: 14,94,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4569 No. of Facilities: 15 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 15 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R22;R34

[ Safety Phrases ]:
S26-S36-S45-S36/37/39

[ RIDADR ]:
2811

[ WGK Germany ]:
3

[ RTECS ]:
AJ1530000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1,4-Dioxan-2-one
  • Formaldehyde
  • carbon monoxide
  • trioxane
  • Diglycolic Anhydride
  • Diethyl ether
  • Triamcinolone acetonide
  • Diethylene glycol
  • 2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol
  • Chloroacetic acid

DownStream

  • Diglycolic Anhydride
  • Fluorothyl
  • 2-(1,3-benzothiazol-2-ylmethoxy)acetic acid
  • (2,3,4,5,6-pentafluorophenyl) 2-[2-oxo-2-(2,3,4,5,6-pentafluorophenoxy)ethoxy]acetate
  • hexyl 2-(2-hexoxy-2-oxoethoxy)acetate
  • (Hydroxymethyl)phosphonic acid
  • (oxybis(methylene))diphosphonic acid
  • 2,2'-oxydiacetyl chloride
  • Glycolic acid

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Covalent bridging of surface functionalized Fe3O4 and YPO4:Eu nanostructures for simultaneous imaging and therapy.

Dalton Trans. 44 , 14686-96, (2015)

Magnetic luminescent hybrid nanostructures (MLHN) have received a great deal of attention due to their potential biomedical applications such as thermal therapy, magnetic resonance imaging, drug deliv...

Diglycolic acid is the nephrotoxic metabolite in diethylene glycol poisoning inducing necrosis in human proximal tubule cells in vitro.

Toxicol. Sci. 124 , 35-44, (2011)

Diethylene glycol (DEG), a solvent and chemical intermediate, can produce an acute toxic syndrome, the hallmark of which is acute renal failure due to cortical tubular degeneration and proximal tubula...

Diglycolic acid inhibits succinate dehydrogenase activity in human proximal tubule cells leading to mitochondrial dysfunction and cell death.

Toxicol. Lett. 221(3) , 176-84, (2013)

Diethylene glycol (DEG) is a solvent used in consumer products allowing the increased risk for consumer exposure. DEG metabolism produces two primary metabolites, 2-hydroxyethoxyacetic acid (2-HEAA) a...


More Articles

Related Compounds

  • Diglycolic acid
  • diglycolic acid anhydride
  • diglycolic acid dianilide
  • diselenium diglycolic acid
  • Diglycolic acid calcium salt
  • Diglycolic acid,diallyl ester
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • (3S)-3-amino-1-bromohexan-2-one
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 4,4-Diethoxybut-2-en-1-amine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine