capreomycin

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Names

[ Name ]:
capreomycin

[Synonym ]:
3,6-diamino-N-(((8E)-15-amino-3,6,9,12,16-pentahydroxy-8-(((hydroxy(imino)methyl)amino)methylene)-2-(hydroxymethyl)-11-(2-iminohexahydropyrimidin-4-yl)-1,4,7,10,13-pentaazacyclohexadeca-3,6,9,12,16-pentaen-5-yl)methyl)hexanimidic acid compound with sulfuric acid (1:1)
3,6-Diamino-N-{[(8Z)-15-amino-11-(2-amino-3,4,5,6-tetrahydro-4-pyrimidinyl)-8-[(carbamoylamino)methylene]-2-(hydroxymethyl)-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentaazacyclohexadecan-5-yl]methyl}hexanamide sulfate (1:1)
Hexanamide, 3,6-diamino-N-[[(8Z)-15-amino-8-[[(aminocarbonyl)amino]methylene]-11-(2-amino-3,4,5,6-tetrahydro-4-pyrimidinyl)-2-(hydroxymethyl)-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentaazacyclohexadec-5-yl]methyl]-, sulfate (1:1) (salt)

Chemical & Physical Properties

[ Boiling Point ]:
1376.7ºC at 760 mmHg

[ Molecular Formula ]:
C₂₅H₄₆N₁₄O₁₂S

[ Molecular Weight ]:
766.784

[ Flash Point ]:
786.4ºC

[ Exact Mass ]:
766.314026

[ PSA ]:
480.83000

[ Vapour Pressure ]:
0mmHg at 25°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EX8920000

CHEMICAL NAME :: Capreomycin

CAS REGISTRY NUMBER :: 11003-38-6

LAST UPDATED :: 198910

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 1371 mg/kg/96D-I

TOXIC EFFECTS :: Vascular - BP elevation not characterized in autonomic section Nutritional and Gross Metabolic - changes in potassium Nutritional and Gross Metabolic - metabolic alkalosis

REFERENCE :: AJKDDP American Journal of Kidney Diseases. (Grune & Stratton, Inc., Journal Subscription Dept., POB 6280, Duluth, MN 55806) V.1- 1981- Volume(issue)/page/year: 7,245,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 514 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 25,353,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 238 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 25,353,1974

Related Compounds

capreomycin IB
capreomycin IA
capreomycin IIB
capreomycin IIA
Capreomycin Sulfate
Capreomycin disulfate
2-Hydroxy-3-(4-nitrobenzyl)-2,4,6-cycloheptatrien-1-one
(2S)-2-{[(Benzyloxy)carbonyl]amino}-3-(furan-2-yl)propanoic acid
(R)-1-Ethyl-3-methylhexahydropyrimidin-5-amine
1,8-Dioxaspiro[4.6]undecan-11-one
(2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8aR,9S,10R,12aS,14aR,14bR)-9,10-dihydroxy-4-(hydroxymethyl)-4,6a,6b,8a,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,4-dihydroxy-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-2-carboxylic acid
rel-Ethyl (2R,3R)-2-fluoro-3-hydroxyhexanoate
3-(5,5-Dimethyl-1,3-dioxan-2-yl)but-2-enal
(E)-2-Cyanocinnamic acid methyl ester
L-Arabinonic acid, 3,4-O-(1-methylethylidene)-, delta-lactone
2,3,6,7-tetrahydro-3-oxo-Isoxazolo[4,5-c]pyridine-5(4H)-carboxylic acid methyl ester

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