Ascomycin

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Names

[ CAS No. ]:
11011-38-4

[ Name ]:
Ascomycin

[Synonym ]:
immunomycin
ascomycin,streptomyces hygroscopicus
(1R,9S,12S,13R,14S,17R,18Z,21S,23S,24R,25S,27R)-17-Ethyl-1,14-dihydroxy-12-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-propen-2-yl}-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatr ;icyclo[22.3.1.0]octacos-18-ene-2,3,10,16-tetrone
aag
ascomycin /immunomycin/fr-900520/fk-520
15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-, (3S,4R,5S,8R,9Z,12S,14S,15R,16S,18R,19R,26aS)-
fk-520

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
868.3±75.0 °C at 760 mmHg

[ Melting Point ]:
156 -161ºC

[ Molecular Formula ]:
C43H69NO12

[ Molecular Weight ]:
792.008

[ Flash Point ]:
478.9±37.1 °C

[ Exact Mass ]:
791.481995

[ PSA ]:
178.36000

[ LogP ]:
3.81

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.546

[ Storage condition ]:
-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CI7570000
CHEMICAL NAME :
Ascomycin
CAS REGISTRY NUMBER :
11011-38-4
LAST UPDATED :
199212

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 15,231,1962

Safety Information

[ Hazard Codes ]:
Xn

[ Safety Phrases ]:
S36/37

[ RTECS ]:
CI7570000

Related Compounds

  • Ascomycin
  • ascomycin
  • 11-epi-ascomycin
  • 9-deoxo-ascomycin
  • 24,33-bis-OTBDMS-ascomycin
  • 2(R),10(S),11(S)-cyclo-ascomycin
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 4-[(1-Methoxypropan-2-yl)amino]cyclohexan-1-ol
  • Methyl 4-(3-fluorophenyl)furo[3,2-c]pyridine-6-carboxylate
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • [3-(3-Bromo-4-methoxyphenyl)propyl](methyl)amine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 3-Methyl-5-(trifluoromethoxy)-2,3-dihydro-1H-indole
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • 4-chloro-1-(2-methoxyethyl)-1H-pyrazolo[3,4-d]pyrimidine