Higenamine HCl

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Names

[ Name ]:
Higenamine HCl

[Synonym ]:
pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-6(7H)-one
1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol hydrochloride (1:1)
6,7-dihydroxy-1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride
Higenamine HCl
UNII:PQ432PID6E
6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-, hydrochloride (1:1)

Chemical & Physical Properties

[ Boiling Point ]:
522.4ºC at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₈ClNO₃

[ Molecular Weight ]:
307.772

[ Flash Point ]:
209.6ºC

[ Exact Mass ]:
307.097534

[ PSA ]:
72.72000

[ LogP ]:
3.36370

[ Vapour Pressure ]:
1.56E-11mmHg at 25°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NX0484380

CHEMICAL NAME :: 6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-((4-hydroxyphenyl)methyl)-, hydrochloride, (+-)-

CAS REGISTRY NUMBER :: 11041-94-4

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H17-N-O3.Cl-H

MOLECULAR WEIGHT :: 307.80

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 17250 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,489,1982

Safety Information

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4-Benzyloxyphenylacetonitrile
TRANS-3 4-BENZYLOXY-TRANS-B-NITROSTYREN&
4-Benzyloxyphenylacetyl Chloride
[4-(Benzyloxy)phenyl]acetic acid
3,4-Dibenzyloxyphenethylamine hydrochloride
N-(3,4-dibenzyloxyphenethyl)-4-benzyloxyphenylacetamide
6,7-bisbenzyloxy-1-(4-benzyloxybenzyl)-3,4-dihydroisoquinoline hydrochloride

DownStream

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%