N-Methylparoxetine

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Names

[ CAS No. ]:
110429-36-2

[ Name ]:
N-Methylparoxetine

[Synonym ]:
Piperidine, 3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-1-methyl-
Paroxetine Related Compound F
3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-1-methylpiperidine
Piperidine, 3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-1-methyl-, (3S,4R)-
(3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)-1-methylpiperidine
MFCD03788781
N-Methyl Paroxetine
(3S,4R)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-1-methylpiperidine
Paroxetine Impurity 9

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
443.7±45.0 °C at 760 mmHg

[ Melting Point ]:
111 °C

[ Molecular Formula ]:
C20H22FNO3

[ Molecular Weight ]:
343.392

[ Flash Point ]:
222.1±28.7 °C

[ Exact Mass ]:
343.158386

[ PSA ]:
30.93000

[ LogP ]:
3.91

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.562

[ Storage condition ]:
Hygroscopic, -20°C Freezer, Under Inert Atmosphere

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H410

[ Precautionary Statements ]:
P273-P301 + P310-P501

[ Hazard Codes ]:
T,N

[ Risk Phrases ]:
25-50/53

[ Safety Phrases ]:
45-60-61

[ RIDADR ]:
UN 2811 6.1 / PGIII

[ Hazard Class ]:
6.1

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Sesamol
  • Paroxol Tosylate
  • Paroxetine hydrochloride hydrate
  • methyl iodide
  • (3S,4R)-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine
  • 4-Fluorobenzaldehyde

DownStream

  • Paroxetine
  • Paroxetine hydrochloride hydrate

Articles

Depletion of selective serotonin reuptake inhibitors during sewage sludge composting.

Waste Manag. 29(11) , 2808-15, (2009)

Sewage and sewage sludge is known to contain pharmaceuticals, and since sewage sludge is often used as fertilizer within agriculture, the reduction of the selective serotonin reuptake inhibitors (SSRI...


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Related Compounds

  • N,N'-bis[2-(3,4-dimethoxyphenyl)ethyl]-N,N'-dimethylpropane-1,3-diamine
  • N-octanoyl benzotriazole
  • N-[4-[(6-chloro-[1,3]dioxolo[4,5-b]acridin-10-yl)amino]-3-methoxyphenyl]methanesulfonamide
  • N-(diaminomethylidene)pyrrolidine-1-carboximidamide,hydrochloride
  • N-phenyl-[1,3]dioxolo[4,5-b]acridin-10-amine
  • N-[bis(diethylamino)silyl]-N-ethylethanamine
  • 3,6-Dichloro-4-isocyanatopyridazine
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • tert-butyl N-methyl-N-{[3-(sulfamoylmethyl)phenyl]methyl}carbamate
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 2-(Difluoromethoxy)pyridine-3-sulfonyl fluoride
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • 1-(3-Hydroxy-8,8-dioxo-8lambda6-thiabicyclo[3.2.1]octan-3-yl)cyclopropane-1-carboxylic acid
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide