CP 73850

[ Density]:
1.58g/cm3

[ Boiling Point ]:
598.7ºC at 760mmHg

[ Molecular Formula ]:
C₁₉H₁₂F₃N₃O₃S

[ Molecular Weight ]:
419.37700

[ Flash Point ]:
315.9ºC

[ Exact Mass ]:
419.05500

[ PSA ]:
113.32000

[ LogP ]:
3.70040

[ Vapour Pressure ]:
3.5E-15mmHg at 25°C

[ Index of Refraction ]:
1.683

Click to get detail MSDS

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H413

[ Precautionary Statements ]:
P301 + P310

[ Hazard Codes ]:
T+

[ RIDADR ]:
UN 2811 6.1 / PGIII

Inhibiting wild-type and C299S mutant AKR1B10; a homologue of aldose reductase upregulated in cancers.

Eur. J. Pharmacol. 584 , 213-221, (2008)

AKR1B10 is an aldose reductase (AR) homologue overexpressed in liver cancer and various forms of that enzyme in carcinomas catalyze the reduction of anticancer drugs, potential cytostatic drug, and dl...

Mediation of aldose reductase in lipopolysaccharide-induced inflammatory signals in mouse peritoneal macrophages.

Cytokine 36(3-4) , 115-22, (2006)

Aldose reductase (AR; AKR1B1) a member of aldo-keto reductase super family, that we had shown earlier mediates cytotoxic signals induced by high glucose, cytokines and growth factors, also mediates th...

Endotoxin causes pulmonary hypertension by upregulating smooth muscle endothelin type-B receptors: role of aldose reductase.

Shock 30(2) , 189-96, (2008)

Endothelin-1 (ET-1), a potent vasoconstrictor and mitogen, is upregulated in pulmonary tissue during endotoxemia and contributes markedly to endotoxin-induced pulmonary hypertension. It is, however, u...

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