2-Chloro-4,5-difluorobenzoic acid

Names

[ Name ]:
2-Chloro-4,5-difluorobenzoic acid

[Synonym ]:
Benzoic acid, 2-chloro-4,5-difluoro-
2-chloro-4,5-difluoro-benzoic acid
QVR BG DF EF
MFCD00077479
2-chloro-4,-difluorobenzoic acid
2-Chloro-4,5-difluorobenzoic acid
EINECS 405-380-5

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
273.8±35.0 °C at 760 mmHg

[ Melting Point ]:
103-106 °C(lit.)

[ Molecular Formula ]:
C₇H₃ClF₂O₂

[ Molecular Weight ]:
192.547

[ Flash Point ]:
119.4±25.9 °C

[ Exact Mass ]:
191.978958

[ PSA ]:
37.30000

[ LogP ]:
1.90

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.535

[ Water Solubility ]:
5.0 g/L (20 ºC)

MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R21/22;R41;R43

[ Safety Phrases ]:
S26-S39-S36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
4002191900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2''-Chloro-4'',5''-difluoroacetophenone
2-Amino-4,5-difluorobenzoic acid
t-butyl nitrite
1-chloro-4,5-difluoro-2-(trichloromethyl)benzene
4-Chloro-1-fluoro-2-nitrobenzene
1,4-Dichloro-2-nitrobenzene
5-Chloro-2-fluoroaniline
4-Chloro-1,2-difluorobenzene
2-chloro-1-(2-chloro-4,5-difluorophenyl)ethanone
1,2-Difluorobenzene

DownStream

4-chloro-2,6-difluorobenzyl alcohol
Methyl 2-chloro-4,5-difluorobenzoate
2-Chloro-4,5-difluorobenzoyl chloride

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Crystal structures and thermodynamic properties of lanthanide complexes with 2-chloro-4, 5-difluorobenzoate and 1, 10-phenanthroline. Tang K, et al.

J. Chem. Thermodyn. 56 , 38-48, (2013)

Syntheses of 2-Chloro-4, 5-difluorobenzoic Acid. Li Z and Huang N.

Org. Prep. Proced. Int. 28(2) , 245-46, (1996)

3-Bromo-2-chloro-4,5-difluorobenzoic acid
2-Chloro-4,5-difluorobenzoic acid methyl ester
3-Chloro-4,5-difluorobenzoic acid
2-chloro-4,5-dihydroxybenzoic acid
2-Chloro-4,5-difluorophenylboronic acid, pinacol ester
2-CHLORO-4,5-DIFLUOROPHENYLACETIC ACID
3-(Methacryloyloxy)-2-hydroxypropyl anthracene-9-carboxylate
2-(2-(3-Cyanophenyl)ethenyl)benzthiazole
2-(3,3,3-Trifluoropropyl)oxirane
2,4-Dithiothymidine
N,N'-bis(3,5-dimethylphenyl)propanediamide
Dioxopiperazinylpropan
L-Leucinamide, L-alanyl-
Cys-Ser
1-(Trifluoromethyl)cyclopentanecarbaldehyde
2-Amino-4-(tert-butyl)pyrimidine-5-carbonitrile

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