(S)-(+)-2-(Dibenzylamino)-3-phenyl-1-propanol

Names

[ CAS No. ]:
111060-52-7

[ Name ]:
(S)-(+)-2-(Dibenzylamino)-3-phenyl-1-propanol

[Synonym ]:
(2S)-2-(dibenzylamino)-3-phenylpropan-1-ol
MFCD00191984

Chemical & Physical Properties

[ Density]:
1.111g/cm3

[ Boiling Point ]:
488ºC at 760mmHg

[ Melting Point ]:
72-74 °C(lit.)

[ Molecular Formula ]:
C₂₃H₂₅NO

[ Molecular Weight ]:
331.45100

[ Flash Point ]:
191.3ºC

[ Exact Mass ]:
331.19400

[ PSA ]:
23.47000

[ LogP ]:
4.29240

[ Vapour Pressure ]:
2.45E-10mmHg at 25°C

[ Index of Refraction ]:
1.613

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2922199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

H-Phe-ol
Benzyl bromide
benzyl n,n-dibenzyl-l-phenylalaninate
Benzaldehyde
(2S,3S)-3-(dibenzylamino)-2-hydroxy-4-phenylbutanenitrile
L-Phenylalanine
N,N-Dibenzyl-L-phenylalanine
2S-[bis(phenylmethyl)amino]benzenepropanaldehyde

DownStream

(2R,3S)-3-(tert-Butoxycarbonyl)aMino-1,2-epoxy-4-phenylbutane
tert-Butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
tert-Butyl [(1S,2R)-1-Benzyl-2-hydroxy-3-(isobutylamino)propyl]carbamate
L-Phenylalanine hydrochloride
N-Benzoyl-L-phenylalanine

Customs

[ HS Code ]: 2922199090

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Preparation of Aminoalkyl Chlorohydrin Hydrochlorides: Key Building Blocks for Hydroxyethylamine-Based HIV Protease Inhibitors.

J. Org. Chem. 61 , 3635, (1996)

Enantiomerically pure N,N-dibenzyl-alpha-amino aldehydes reacted with (chloromethyl)lithium, generated in situ from bromochloromethane and lithium metal, to give predominantly erythro aminoalkyl epoxi...

Stereoselective Synthesis of HIV-1 Protease Inhibitor, DMP 323.

J. Org. Chem. 61 , 444, (1996)

DMP 323, a potent HIV-1 protease inhibitor, has been synthesized by an efficient stereoselective process, amenable to large scale preparations. The core C(2) symmetric diol was synthesized by a stereo...

Cyclic HIV protease inhibitors: synthesis, conformational analysis, P2/P2' structure-activity relationship, and molecular recognition of cyclic ureas.

J. Med. Chem. 39 , 3514, (1996)

High-resolution X-ray structures of the complexes of HIV-1 protease (HIV-1PR) with peptidomimetic inhibitors reveal the presence of a structural water molecule which is hydrogen bonded to both the mob...

(S)-(+)-2-DIBENZYLAMINO-3-PHENYL-1-PROPANOL
(S)-(+)-2-(DIBENZYLAMINO)-1-PROPANOL
(R)-(-)-1-CYCLOHEXYLETHYLAMINE
(2S)-2-(Dibenzylamino)-1-propanol
(S)-(-)-2-methyl-3-phenyl-1-propanol
(S)-(-)-2-PHENYL-1-PROPANOL
2-[(2,4-Difluorophenyl)amino]pyrimidine-4-carbonitrile
4-[(5-Chloro-2-thienyl)methoxy]-I+/--ethylbenzenemethanamine
2-(1-Amino-2-methoxycyclohexyl)acetic acid
4-(4,4-Difluoropiperidin-1-yl)benzoic acid
Methyl 5-methoxy-1-oxaspiro[2.5]octane-2-carboxylate
5-(Dimethylamino)-2-pyrazinecarboxamide
Ethyl 4-methoxy-1-oxaspiro[2.5]octane-2-carboxylate
2-(3-Methoxyphenyl)-6-methylimidazo[1,2-a]pyridine
Ethyl 5-methoxy-1-oxaspiro[2.5]octane-2-carboxylate
CID 60889126

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