acetyldigitoxin

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Names

[ Name ]:
acetyldigitoxin

[Synonym ]:
Acetildigitoxina
3'''-Acetyldigitoxin
Digitoxigenin 3-O-bisdigitoxosidoacetodigitoxoside
Acetyldigitoxinum
3'"-O-acetyl digitoxin
digitoxin 3"'-acetate
EINECS 214-178-4
ACETYLDIGITOXIN
acylanid
adicin
Acedigal
Acetyl-digitoxine

Chemical & Physical Properties

[ Density]:
1.31g/cm3

[ Boiling Point ]:
902.2ºC at 760 mmHg

[ Melting Point ]:
217-221°

[ Molecular Formula ]:
C₄₃H₆₆O₁₄

[ Molecular Weight ]:
806.97600

[ Flash Point ]:
265ºC

[ Exact Mass ]:
806.44500

[ PSA ]:
188.90000

[ LogP ]:
3.81810

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.582

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: IH2450000

CHEMICAL NAME :: Digitoxin, acetate, alpha-

CAS REGISTRY NUMBER :: 1111-39-3

BEILSTEIN REFERENCE NO. :: 0077291

LAST UPDATED :: 199612

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C43-H66-O14

MOLECULAR WEIGHT :: 807.09

WISWESSER LINE NOTATION :: L E5 B666TJ A1 E1 IOV1 F- DT5OV EHJ& OO- FT6OTJ B1 DQ CO- FT6OTJ B1 DQ CO- FT6OTJ B1 CQ DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 54,58,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2780 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - food intake (animal) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,170,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 250 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 159,1,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 514 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 111,365,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: >30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 159,1,1966

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 15,481,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 2800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,170,1980 *** REVIEWS *** TOXICOLOGY REVIEW 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,187,1963

Safety Information

[ RIDADR ]:
UN 3249

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

Synthetic Route

Click to get detail synthetic route

Related Compounds

Acetyldigitoxinum
Acetyldigitoxinum
2-(6-(Tetrahydro-2h-pyran-4-ylamino)imidazo[1,2-b]pyridazin-3-yl)benzonitrile
Tert-butyl 4-((5-(hydroxymethyl)-2-methoxyphenoxy)methyl)piperidine-1-carboxylate
(3R)-3-cyclohexyl-3-acetamidopropanoic acid
Tert-butyl 4-((5-(cyanomethyl)-2-methoxyphenoxy)methyl)piperidine-1-carboxylate
Phenylmethyl (I+/-S)-I+/--(cyclopentylmethyl)-4-(cyclopropylsulfonyl)-2-oxo-1(2H)-pyridineacetate
Methyl 2-[(2-bromoethyl)oxy]-5-nitro-3-[(phenylcarbonyl)oxy]benzoate
5-Methyl-2-(2-nitroethenyl)phenol
Methyl 2-{[2-(methyloxy)ethyl]oxy}-5-nitro-3-[(phenylcarbonyl)oxy]benzoate
Ethyl 2-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2,2-difluoroacetate
4-(Chloromethyl)-1,2-bis{[2-(methyloxy)ethyl]oxy}benzene

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