N-Acetyl-DL-methionine

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Names

[ Name ]:
N-Acetyl-DL-methionine

[Synonym ]:
Methionine, N-acetyl-, DL-
2-(acetylamino)-4-(methylthio)butanoic acid
2-acetamido-4-methylsulfanylbutanoic acid
2-Acetamido-4-(methylthio)butanoic acid
N-acetyl-methionine
DL-Methionine, N-acetyl-
Methionine, N-acetyl-
ACETYL-DL-METHIONINE
N-Acetylmethionine
UNII:383941IGXN
Methionamine
MFCD00008681
Ac-DL-Met-OH
DL-N-Acetylmethionine
EINECS 214-224-3

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
453.6±40.0 °C at 760 mmHg

[ Melting Point ]:
117-119 °C(lit.)

[ Molecular Formula ]:
C₇H₁₃NO₃S

[ Molecular Weight ]:
191.248

[ Flash Point ]:
228.1±27.3 °C

[ Exact Mass ]:
191.061615

[ PSA ]:
91.70000

[ LogP ]:
-0.19

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.511

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PD0500000

CHEMICAL NAME :: Methionine, N-acetyl-, DL-

CAS REGISTRY NUMBER :: 1115-47-5

BEILSTEIN REFERENCE NO. :: 1725554

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H13-N-O3-S

MOLECULAR WEIGHT :: 191.27

WISWESSER LINE NOTATION :: 1VMYVQ2S1 -DL

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 91,163,1952

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
PD0500000

[ HS Code ]:
2930909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

D-methionine
L-Methionine
N-acetyl-L-methionine
N-Acetyl-DL-methionine
N-(3-methylsulfanyl-9H-fluoren-2-yl)acetamide
N-(1-methylsulfanyl-9H-fluoren-2-yl)acetamide
N-Acetyl-L-methionine methylester
acetic acid
DL-Methionine
H-Met-Met-OH

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Importance of product inhibition in the kinetics of the acylase hydrolysis reaction by differential stopped flow microcalorimetry.

Anal. Biochem. 308 , 285-293, (2002)

The hydrolysis of N-acetyl-L-methionine, N-acetylglycine, N-acetyl-L-phenylalanine, and N-acetyl-L-alanine at 298.35K by porcine kidney acylase I (EC 3.5.1.14) was monitored by the heat released upon ...

Model sclerotization studies. 4. Generation of N-acetylmethionyl catechol adducts during tyrosinase-catalyzed oxidation of catechols in the presence of N-acetylmethionine.

Arch. Insect Biochem. Physiol. 38(1) , 44-52, (1998)

Incubation of catechol with mushroom tyrosinase in the presence of N-acetylmethionine resulted in the generation of an adduct. This product was identified to be N-acetylmethionyl catechol, on the basi...

Identification of N-acetylmethionine as the product released during the NH2-terminal processing of a pseudo-class I actin.

J. Biol. Chem. 264(19) , 11491-6, (1989)

Genes for the various isoactins define two classes of actin. Class I actin genes code for Met-Asp(Glu)-actin, and class II actin genes code for Met-X-Asp(Glu)-actin where X is usually cysteine. Amino ...