Temocapril

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Names

[ CAS No. ]:
111902-57-9

[ Name ]:
Temocapril

[Synonym ]:
2-[(2S)-6-[[(2S)-1-ethoxy-1-oxo-4-phenyl-butan-2-yl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]ethanoic acid
2-[(2S)-6-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid
TemocaprilnDiscontinued
2-[(2S)-6-[[(1S)-1-carbethoxy-3-phenyl-propyl]amino]-5-keto-2-(2-thienyl)-1,4-thiazepan-4-yl]acetic acid
TEMOCAPRIL
2-((2S,6R)-6-((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-ylamino)-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-4-yl)aceticacid
Temocapil

Chemical & Physical Properties

[ Density]:
1.33 g/cm3

[ Boiling Point ]:
717.4ºC at 760 mmHg

[ Melting Point ]:
>230ºC (dec)

[ Molecular Formula ]:
C23H28N2O5S2

[ Molecular Weight ]:
476.60900

[ Flash Point ]:
387.7ºC

[ Exact Mass ]:
476.14400

[ PSA ]:
149.48000

[ LogP ]:
3.30070

[ Storage condition ]:
-20℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (S)-ethyl 2-(((2S,6R)-4-(2-(tert-butoxy)-2-oxoethyl)-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-6-yl)amino)-4-phenylbutanoate
  • (R)-2-<(4-nitrobenzolsulfonyl)oxy>-4-phenylbuttersaeure-ethylester
  • (2R,6R)-6-AMINO-5-OXO-2-(2-THIENYL)PERHYDRO-1,4-THIAZEPINE
  • tert-Butyl (2S,6R)-6-amino-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepine-4-acetate
  • (2R,6R)-2-(thiophen-2-yl)-6-(tritylamino)-1,4-thiazepan-5-one
  • (R)-tert-butyl 2-(5-oxo-2-(thiophen-2-yl)-6-(tritylamino)-6,7-dihydro-1,4-thiazepin-4(5H)-yl)acetate
  • tert-butyl 2-((2S,6R)-5-oxo-2-(thiophen-2-yl)-6-(tritylamino)-1,4-thiazepan-4-yl)acetate
  • tert-butyl 2-((2R,6R)-5-oxo-2-(thiophen-2-yl)-6-(tritylamino)-1,4-thiazepan-4-yl)acetate

DownStream

  • Ethanol
  • Temocaprilat

Related Compounds

  • Temocaprilat
  • Temocapril-d5
  • Temocapril HCl
  • N-cyclopropyl-1-(1,3,4-thiadiazol-2-yl)piperidine-4-carboxamide
  • N-tert-butyl-1-(pyridin-2-yl)pyrrolidine-3-carboxamide
  • N-tert-butyl-1-(5-fluoropyridin-2-yl)pyrrolidine-3-carboxamide
  • 1-(3-chloro-5-cyanopyridin-2-yl)-N-cyclopropylpiperidine-4-carboxamide
  • 1-(5-bromo-3-cyanopyridin-2-yl)-N-cyclopropylpiperidine-4-carboxamide
  • N-tert-butyl-1-(6-tert-butylpyridazin-3-yl)pyrrolidine-3-carboxamide
  • (2-(3-Chlorobenzyl)phenyl)methanol
  • 2-{4-[(7-fluoro-4-oxo-3,4-dihydroquinazolin-3-yl)methyl]piperidin-1-yl}-N-(2-methoxyphenyl)acetamide
  • N-[1-(5-tert-butyl-1,3,4-thiadiazol-2-yl)piperidin-3-yl]cyclopropanecarboxamide
  • 1-Fluoro-2-methoxy-3-(nitromethyl)benzene