2-(hexyloxy)ethanol

Names

[ CAS No. ]:
112-25-4

[ Name ]:
2-(hexyloxy)ethanol

[Synonym ]:
2-(HEXYLOXY)ETHANOL
2-(Hexyloxy)ethanol C6E1 Hexylglycol
Hexyl Cellosolve
Ethylene Glycol Monohexyl Ether
EINECS 203-951-1
MFCD00045997

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
206.3±8.0 °C at 760 mmHg

[ Melting Point ]:
-45.1ºC

[ Molecular Formula ]:
C₈H₁₈O₂

[ Molecular Weight ]:
146.227

[ Flash Point ]:
60.5±6.3 °C

[ Exact Mass ]:
146.130676

[ PSA ]:
29.46000

[ LogP ]:
1.86

[ Vapour Pressure ]:
0.1±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.429

[ Storage condition ]:
-15°C

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KL2450000

CHEMICAL NAME :: Ethanol, 2-(hexyloxy)-

CAS REGISTRY NUMBER :: 112-25-4

BEILSTEIN REFERENCE NO. :: 1734691

LAST UPDATED :: 199710

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C8-H18-O2

MOLECULAR WEIGHT :: 146.26

WISWESSER LINE NOTATION :: Q2O6

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 1/19/1958

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 1/19/1958 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 830 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - other changes

REFERENCE :: VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 29,361,1987

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >83 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 8,198,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 737 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 66,368,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 810 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Gastrointestinal - changes in structure or function of salivary glands Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 29,361,1987 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 84 ppm/6H/11D-I

TOXIC EFFECTS :: Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 8,198,1987

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 41 ppm/6H/13W-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 8,198,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3116 No. of Facilities: 269 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 3496 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M3116 No. of Facilities: 31 (estimated) No. of Industries: 5 No. of Occupations: 7 No. of Employees: 2872 (estimated) No. of Female Employees: 45 (estimated)

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H311-H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C: Corrosive;

[ Risk Phrases ]:
R21/22

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 2922 8/PG 3

[ WGK Germany ]:
1

[ RTECS ]:
KL2450000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2909499000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1-Bromohexane
Ethylene glycol
2-hexoxyethanol,4-methylbenzenesulfonic acid
Potassium phthalimide
ETHYLENE OXIDE
1-Hexanol

DownStream

2-(hexyloxy)ethyl laurate
2-hexoxyethyl nonanoate
2-hexoxyethyl tetradecanoate
2-hexoxyethyl octanoate
2-hexoxyethyl decanoate
TRIETHYLENE GLYCOL MONOHEXYL ETHER
Diethylene glycol monohexyl ether
1-Bromohexane
(2-bromo-ethyl)-hexyl ether
2-hexoxyethanol,4-methylbenzenesulfonic acid

Customs

[ HS Code ]: 2909499000

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

Acute, 9-day, and 13-week vapor inhalation studies on ethylene glycol monohexyl ether.

Fundam. Appl. Toxicol. 8(2) , 198-206, (1987)

At ambient conditions, the low vapor pressure of ethylene glycol monohexyl ether (EGHE) allows for a maximum vapor concentration of approximately 85 ppm. In an acute inhalation study on Wistar albino ...

The comparative acute toxicity and primary irritancy of the monohexyl ethers of ethylene and diethylene glycol.

Vet. Hum. Toxicol. 29(5) , 361-6, (1987)

Ethylene glycol monohexyl ether (EGHE) and diethylene glycol monohexyl ether (DGHE) are glycol ethers used as industrial solvents and coating materials, and whose acute handling hazards were investiga...

Evaluation of the developmental toxicity of ethylene glycol monohexyl ether vapor in Fischer 344 rats and New Zealand white rabbits.

Fundam. Appl. Toxicol. 12(2) , 269-80, (1989)

Timed pregnant Fischer 344 rats and New Zealand White rabbits were exposed to vapor from ethylene glycol monohexyl ether (EGHE, CAS No. 112-25-4) for 6 hr/day on gestational days (gd) 6 through gd 15 ...

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