2-Ethoxyethyl ether

Names

[ CAS No. ]:
112-36-7

[ Name ]:
2-Ethoxyethyl ether

[Synonym ]:
EINECS 203-963-7
Diethylene Glycol Diethyl Ether
Diethyldiglycol
Bis(2-ethoxyethyl) Ether
MFCD00009254
Diethyl Carbitol
2-Ethoxyethyl ether

Chemical & Physical Properties

[ Density]:
0.909 g/mL at 25 °C(lit.)

[ Boiling Point ]:
180-190 °C(lit.)

[ Melting Point ]:
-44.3 °C

[ Molecular Formula ]:
C₈H₁₈O₃

[ Molecular Weight ]:
162.22700

[ Flash Point ]:
160 °F

[ Exact Mass ]:
162.12600

[ PSA ]:
27.69000

[ LogP ]:
1.07600

[ Vapour density ]:
5.6 (vs air)

[ Vapour Pressure ]:
0.758mmHg at 25°C

[ Index of Refraction ]:
n20/D 1.412(lit.)

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents. May form peroxides on exposure to air - test for their presence before heating.

[ Water Solubility ]:
SOLUBLE

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KN3160000

CHEMICAL NAME :: Ether, bis(2-ethoxyethyl)

CAS REGISTRY NUMBER :: 112-36-7

BEILSTEIN REFERENCE NO. :: 1699259

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C8-H18-O3

MOLECULAR WEIGHT :: 162.26

WISWESSER LINE NOTATION :: 2O2O2O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 4/25/1958 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4970 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 4/25/1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 6700 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 4/25/1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1850 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,259,1941 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 24 gm/kg

SEX/DURATION :: female 7-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 57,141,1984

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 3 gm/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB88-168257 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84038 No. of Facilities: 1327 (estimated) No. of Industries: 7 No. of Occupations: 8 No. of Employees: 3060 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84038 No. of Facilities: 172 (estimated) No. of Industries: 3 No. of Occupations: 5 No. of Employees: 3489 (estimated) No. of Female Employees: 2128 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R19

[ Safety Phrases ]:
S26-S36

[ WGK Germany ]:
2

[ RTECS ]:
KN3160000

[ HS Code ]:
29091900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

2-diphenylarsanylethyl(diphenyl)arsane
4-Butoxyanilin
isopentane
3-Methyl-1-butyne
3-Methylbut-1-ene
2-butene
Allene
Propyne
Oxirane,3-methoxy-2,2-dimethyl-
1,4-Dioxane

Customs

[ HS Code ]: 2909199090

[ Summary ]:
2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

Results of testing fifteen glycol ethers in a short-term in vivo reproductive toxicity assay.

Environ. Health Perspect. 57 , 141-6, (1984)

Fifteen glycol ethers were investigated for their potential to cause adverse reproductive toxic effects using an in vivo mouse screening bioassay. Pregnant mice were orally dosed once per day on days ...

Density, viscosity, and surface tension at 293.15 K and liquid-liquid equilibria from 301.15 K to 363.15 K under atmospheric pressure for the binary mixture of diethylene glycol diethyl ether+ water. Li XX, et al.

J. Chem. Eng. Data 49(4) , 1043-1045, (2004)

Excess molar volumes and viscosities of binary mixtures of diethylene glycol diethyl ether with chloroalkanes at 298.15 K. Pal A and Bhardwaj RK.

J. Mol. Liq. 102(1) , 197-211, (2003)