Stearoyl chloride

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Names

[ CAS No. ]:
112-76-5

[ Name ]:
Stearoyl chloride

[Synonym ]:
Octadecanoyl chloride
n-octadecanoic acid chloride
Stearoyl chloride
1-octadecanecarboxylic chloride
Octadecanoic acid,chloride
Stearic chloride
MFCD00000744
stearic acid chloride
EINECS 204-004-5
Stearyl chloride

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
347.8±5.0 °C at 760 mmHg

[ Melting Point ]:
21-22 °C(lit.)

[ Molecular Formula ]:
C₁₈H₃₅ClO

[ Molecular Weight ]:
302.923

[ Flash Point ]:
169.8±8.0 °C

[ Exact Mass ]:
302.237640

[ PSA ]:
17.07000

[ LogP ]:
8.96

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.453

[ Water Solubility ]:
hydrolysis

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RG2162000

CHEMICAL NAME :: Octadecanoyl chloride

CAS REGISTRY NUMBER :: 112-76-5

BEILSTEIN REFERENCE NO. :: 0639784

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C18-H35-Cl-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7500 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 28(12),56,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4162 No. of Facilities: 29 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 95 (estimated) No. of Female Employees: 68 (estimated)

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Supplemental HS ]:
Reacts violently with water.

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R14;R34

[ Safety Phrases ]:
S26-S36/37/39-S43-S45

[ RIDADR ]:
UN 3261 8/PG 2

[ WGK Germany ]:
2

[ RTECS ]:
RG2162000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2915900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

(2S)-2-(octadecanoylamino)butanedioic acid
2-Chloroethyl stearate
2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl stearate
octyl stearate
Octadecanehydrazide
Decyl stearate
Lignoceric acid
Lauryl stearate
Melissic acid
Pentacosylic acid

Customs

[ HS Code ]: 2915900090

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

Articles

Incorporation of chemically modified proteins into liposomes.

Acta Biol. Med. Ger. 40(3) , 331-5, (1981)

Enzymes, not anchored into bilayers of membranes like trypsin, alpha-chymotrypsin, and carboxypeptidase A are chemically modified by acylation with fatty acids chlorides. This treatment renders these ...

Encapsulation of fish oil with N-stearoyl O-butylglyceryl chitosan using membrane and ultrasonic emulsification processes.

Carbohydr. Polym. 123 , 432-42, (2015)

Fish oil-loaded microcapsules were prepared from oil-in-water emulsions using N-stearoyl O-butylglyceryl chitosan as shell material. The emulsions were prepared by both membrane and ultrasonic emulsif...

A new and efficient strategy for the synthesis of shimofuridin analogs: 2'-O-(4-O-stearoyl-alpha-L-fucopyranosyl)thymidine and -uridine.

Carbohydr. Res. 338(1) , 55-60, (2003)

Two shimofuridin analogs: 2'-O-(4-O-stearoyl-alpha-L-fucopyranosyl)thymidine (2) and -uridine (3) have been synthesized using D-arabinose, L-fucose, thymine, uracil, and stearoyl chloride as the start...