5-Iodocytosine

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Names

[ CAS No. ]:
1122-44-7

[ Name ]:
5-Iodocytosine

[Synonym ]:
4-amino-5-iodo-1H-pyrimidin-2-one
6-Amino-5-iodpyrimidin-2(1H)-on
2(1H)-Pyrimidinone, 4-amino-5-iodo-
5-Iodocytosine
4-Amino-5-iodopyrimidin-2(1H)-one
CYTOSINE,5-IODO
4-Amino-5-iodo-2(1H)-pyrimidinone
6-amino-5-iodopyrimidin-2(1H)-one
MFCD00023162
5-IODO CYTOSINE
4-Amino-5-iodo-2-pyrimidinol
2-pyrimidinol, 4-amino-5-iodo-
4-Amino-2-hydroxy-5-iodopyrimidine
4-Amino-5-jod-1H-pyrimidin-2-on
4-Amino-5-iodopyrimidin-2-ol

Chemical & Physical Properties

[ Density]:
2.7±0.1 g/cm3

[ Boiling Point ]:
480.2ºC at 760mmHg

[ Molecular Formula ]:
C4H4IN3O

[ Molecular Weight ]:
236.999

[ Flash Point ]:
244.2ºC

[ Exact Mass ]:
236.939896

[ PSA ]:
71.77000

[ LogP ]:
-0.87

[ Vapour Pressure ]:
7.64E-10mmHg at 25°C

[ Index of Refraction ]:
1.852

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HA6125000
CHEMICAL NAME :
Cytosine, 5-iodo-
CAS REGISTRY NUMBER :
1122-44-7
LAST UPDATED :
199012
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C4-H4-I-N3-O
MOLECULAR WEIGHT :
237.01
WISWESSER LINE NOTATION :
T6MVNJ DZ EI

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 13,1249,1964

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
HA6125000

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • cytosine

DownStream

  • 5-iodo-N,N-bis(trimethylsilyl)-2-trimethylsilyloxypyrimidin-4-amine

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Enzymatic primer-extension with glycerol-nucleoside triphosphates on DNA templates.

PLoS ONE 4(3) , e4949, (2009)

Glycerol nucleic acid (GNA) has an acyclic phosphoglycerol backbone repeat-unit, but forms stable duplexes based on Watson-Crick base-pairing. Because of its structural simplicity, GNA is of particula...

Preparation and properties of oligodeoxynucleotides containing 5-iodouracil and 5-bromo- and 5-iodocytosine.

Bioconjug. Chem. 8(5) , 757-61, (1997)

The behavior of oligonucleotides containing 5-iodouracil, 5-bromocytidine, and 5-iodocytidine in concentrated ammonia is described. 5-Aminouracil and 5-aminocytidine are obtained as side products when...

Photochemistry of halogen pyrimidines: iodine release studies.

Photochem. Photobiol. 56(1) , 9-15, (1992)

The feasibility of using direct iodide (I-) measurements to monitor the photochemistry of the halogenated pyrimidines 5-iodocytosine and 5-iodouracil and their corresponding deoxynucleosides was exami...


More Articles

Related Compounds

  • 1-D-Ribofuranosyl-5-iodocytosine
  • 1-(2-Deoxy-2-fluoro-b-D-arabinofuranosyl)-5-iodocytosine
  • 1-(2,3,5-tri-O-acetyl-β-D-arabinofuranosyl)-5-iodocytosine
  • 3',5'-di-O-acetyl-2'-deoxy-2'-fluoro-5-iodocytosine hydrochloride
  • 2,2'-anhydro-1-(3'-O-acetyl-beta-arabinofuranosyl)-5-iodocytosine
  • 1-(2,5-dideoxy-2-fluoro-5-iodo-β-D-arabinofuranosyl)-5-iodocytosine
  • 6-(Furan-2-yl)-5-methylhex-5-en-2-amine
  • 1-(4-Cyclopropyl-1,3-thiazol-5-yl)cyclopentan-1-amine
  • Ethyl 4-(1-aminopropan-2-yl)piperidine-1-carboxylate
  • 2,2-Difluoro-2-(2-methyloxolan-3-yl)ethan-1-ol
  • Tributyl(ethyl)phosphonium bis((trifluoromethyl)sulfonyl)amide
  • 2-Hydroxy-3-methyl-3-(5-methylpyridin-2-yl)butanoic acid
  • 3-({3-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]-1-methyl-1H-pyrazol-5-yl}formamido)pentanoic acid
  • (1R)-1-[(6aR)-hexahydro-2H-cyclopenta[b]furan-3a-yl]-2-aminoethan-1-ol
  • 2-chloro-5-[(3S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pentanamido]benzoic acid
  • Tert-butyl 3-(3-methylpyridin-4-yl)piperazine-1-carboxylate
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