tert-Butyl 1,4-diazepane-1-carboxylate

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Names

[ CAS No. ]:
112275-50-0

[ Name ]:
tert-Butyl 1,4-diazepane-1-carboxylate

[Synonym ]:
tert-butyl 1,4-diazepane-1-carboxylate
2-Methyl-2-propanyl 1,4-diazepane-1-carboxylate
tert-Butyl homopiperazine-1-carboxylate
MFCD00276987
1H-1,4-Diazepine-1-carboxylic acid, hexahydro-, 1,1-dimethylethyl ester
1-Boc-homopiperazine
1-BOC-hexahydro-1,4-diazepine

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
277.9±23.0 °C at 760 mmHg

[ Molecular Formula ]:
C10H20N2O2

[ Molecular Weight ]:
200.28

[ Flash Point ]:
121.9±22.6 °C

[ Exact Mass ]:
200.152481

[ PSA ]:
41.57000

[ LogP ]:
0.94

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.464

[ Storage condition ]:
Keep Cold

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
2735.0

[ WGK Germany ]:
3

[ Hazard Class ]:
8.0

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Homopiperazine
  • Di-tert-butyl dicarbonate
  • 2-Bromopyridine
  • 1-(2-Pyridinyl)hexahydro-1H-1,4-diazepine
  • 4-(2-Oxiranylmethoxy)benzeneacetonitrile
  • N-Boc-piperazine

DownStream

  • 1H-1,4-Diazepine,hexahydro-1-(2-propenyl)-(9CI)
  • 1-pyridin-4-yl-1,4-diazepane
  • 1-(6-Bromo-3-pyridyl)homopiperazine
  • Ethyl 4-(1,4-diazepan-1-yl)benzoate
  • 4-[1,4]Diazepan-1-yl-benzonitrile
  • 1-(2-Pyridinyl)hexahydro-1H-1,4-diazepine
  • 1-Phenyl-1,4-diazepane
  • 1-(2-METHOXY-ETHYL)-2,5-DIMETHYL-1H-PYRROLE-3-CARBALDEHYDE
  • 6-Chloro-2-(1,4-diazepan-1-yl)benzo[d]thiazole
  • 1-(2-methylphenyl)-1,4-diazepane

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Synthesis and biological activity of novel 1,4-diazepane derivatives as factor Xa inhibitor with potent anticoagulant and antithrombotic activity.

Bioorg. Med. Chem. 12 , 2179-2191, (2004)

Factor Xa (fXa) is a serine protease involved in the coagulation cascade, which has received great interest as a potential target for the development of new antithrombotic drugs. Herein we report a no...

Yaws CL.

Thermophysical Properties of Chemicals and Hydrocarbons , (2014), 586


More Articles

Related Compounds

  • tert-butyl 1,4-diazepane-1-carboxylate,hydrochloride
  • 1-Boc-6-Hydroxy[1,4]diazepane
  • tert-butyl 3-phenyl-1,4-diazepane-1-carboxylate
  • tert-butyl 5-methyl-1,4-diazepane-1-carboxylate
  • tert-Butyl 5-phenyl-1,4-diazepane-1-carboxylate
  • tert-butyl 4-cyclopropyl-1,4-diazepane-1-carboxylate
  • 3-Quinolinecarboxamide,n-ethyl-1,2-dihydro-4-hydroxy-6-methoxy-1-methyl-2-oxo-n-phenyl-
  • 3-Aminooct-4-enoic acid
  • Methyl 1-benzyl-4-hydroxy-3-pyrrolin-2-one-3-carboxylate
  • Poly[oxy(dimethylsilylene)], I+/--[[3-(4-hydroxy-3-methoxyphenyl)propyl]dimethylsilyl]-I-[[[3-(4-hydroxy-3-methoxyphenyl)propyl]dimethylsilyl]oxy]-
  • 2-[(4-Aminophenyl)thio]-N-(5-methyl-1H-pyrazol-3-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine
  • 2-Butyne-1,4-diol, 1,4-dicyclohexyl-, monobenzoate, (1S,4S)-
  • 4-Amino-1-(2,2,2-trifluoroethyl)pyrrolidin-2-one hydrochloride
  • 2-[(2,3-dihydro-1H-inden-1-yl)(prop-2-yn-1-yl)amino]-N-(3,5-dimethoxyphenyl)acetamide
  • 2-(Difluoromethoxy)-3-methoxyaniline
  • 1-[6-(acetylamino)-4-methylquinolin-2-yl]-N-cycloheptylpiperidine-4-carboxamide
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