8-Azaadenine

Names

[ Name ]:
8-Azaadenine

[Synonym ]:
2H-1,2,3-Triazolo[4,5-d]pyrimidin-7-amine
8-Azaadenine
1H-1,2,3-Triazolo[4,5-d]pyrimidin-7-amine
EINECS 214-375-5
2H-[1,2,3]Triazolo[4,5-d]pyrimidin-7-amine
MFCD00005697

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
563.9±30.0 °C at 760 mmHg

[ Melting Point ]:
>300 °C(lit.)

[ Molecular Formula ]:
C₄H₄N₆

[ Molecular Weight ]:
136.115

[ Flash Point ]:
329.4±11.8 °C

[ Exact Mass ]:
136.049744

[ PSA ]:
93.37000

[ LogP ]:
-0.88

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.875

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XZ5680000

CHEMICAL NAME :: 1H-v-Triazolo(4,5-d)pyrimidin-7-amine

CAS REGISTRY NUMBER :: 1123-54-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C4-H4-N6

MOLECULAR WEIGHT :: 136.14

WISWESSER LINE NOTATION :: T56 BMNN FN HNJ IZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 315 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 20 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
XZ5680000

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4,5,6-Triaminopyrimidine
4,6-Diaminopyrimidine-2-thiol

DownStream

4H-1,2,3-Triazolo(4,5-d)pyrimidin-7-amine, 4-methyl-
3H-1,2,3-Triazolo[4,5-d]pyrimidin-7-amine,3-methyl-
5-(5-amino-2,4,7,8,9-pentazabicyclo[4.3.0]nona-1,3,5,7-tetraen-9-yl)-2-(hydroxymethyl)oxolan-3-ol

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Intracellular generation of ROS by 3,5-dimethylaminophenol: persistence, cellular response, and impact of molecular toxicity.

Toxicol. Sci. 141(1) , 300-13, (2014)

Epidemiological studies have demonstrated extensive human exposure to the monocyclic aromatic amines, particularly to 3,5-dimethylaniline, and found an association between exposure to these compounds ...

Intersystem crossing to excited triplet state of aza analogues of nucleic acid bases in acetonitrile.

J. Phys. Chem. A 113(44) , 12088-93, (2009)

Excited state characteristics of aza analogues of nucleic acid bases, 8-azaadenine (8AA), 5-azacytosine (5AC), 8-azaguanine (8AG), and 6-azauracil (6AU), in acetonitrile solution were comprehensively ...

[Effects of 5-bromouracil and 5-bromodeoxyuridine in combination with 8-aza-adenine on the UV sensitivity of bacteria].

Z. Allg. Mikrobiol. 23(8) , 495-501, (1983)

The presence of 5-bromouracil (BU) as well as 5-bromo-2-deoxyuridine (BUdR) in the cultivation media of bacteria results in the distinct increase of UV sensitivity. With the nucleic acid base analogue...

8-Azaadenine
9-methyl-8-azaadenine
3-methyl-8-azaadenine
2-fluoro-8-azaadenine
7-methyl-8-azaadenine
3-methyl-8-azaadenine
2-(1-Bromo-2-oxopropyl)-6-hydroxycinnamic acid
2-(1,6-Dihydro-6-oxo-9H-purin-9-yl)ethyl 2-methyl-2-propenoate
N-Methyl-N-[(phenylmethoxy)carbonyl]-L-phenylalanine hydrazide
1-(4-Methoxyphenyl)-1-propanone 2-(2,4-dinitrophenyl)hydrazone
N-[[(E)-2,2-dimethylhex-4-enylidene]amino]-2,4-dinitroaniline
2-Quinazolinecarboxylic acid, 4-amino-8-methoxy-, methyl ester
2-[2-(2-Furanylmethylene)hydrazinyl]-4-thiazolecarboxylic acid
Methyl 1,3,4,5-tetrahydrothiopyrano[4,3-b]indole-6-carboxylate
3-Pyridinecarboxylic acid, 5-cyclopropyl-2-ethyl-, ethyl ester
(3S)-3-[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]morpholine

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