CI-994

Suppliers

Names

[ Name ]:
CI-994

[Synonym ]:
Tacedinaline
4-Acetamido-N-(2-aminophenyl)benzamide
4-(Acetylamino)-N-(2-aminophenyl)benzamide
Goe 5549
N-acetyldinaline
Acetyldinaline
Tacedinalina
Benzamide, 4-(acetylamino)-N-(2-aminophenyl)-
CI994
CI-994

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
450.6±30.0 °C at 760 mmHg

[ Melting Point ]:
242 °C(dec.)

[ Molecular Formula ]:
C₁₅H₁₅N₃O₂

[ Molecular Weight ]:
269.298

[ Flash Point ]:
226.3±24.6 °C

[ Exact Mass ]:
269.116425

[ PSA ]:
84.22000

[ LogP ]:
0.96

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.707

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
CU8702023

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4-Acetamidobenzoic acid
o-Phenylenediamine
4-acetamido-N-(2-aminophenyl)benzamide trifluoroacetate salt
tert-Butyl (2-aminophenyl)carbamate
2-Nitroaniline
TERT-BUTYL 3-ACETYLPHENYLCARBAMATE
6-[2-(4-acetylamino-benzoylamino)-phenylcarbamoyloxy]-3,4,5-trihydroxy-tetrahydro-2H-pyran-2-carboxylic acid
6-{4-[(2-(4-acetylamino-benzoylamino)-phenylcarbamoyl)oxymethyl]-2-nitro-phenoxy}-tetrahydro-2H-pyran-2-carboxylic acid

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Role of a small molecular weight phosphoprotein in the mechanism of action of CI-994 (N-acetyldinaline).

Int. J. Cancer 62(5) , 636-42, (1995)

The mechanism of action of the novel anti-cancer compound CI-994 was studied in C26 murine colon tumor and HCT-8 human colon adenocarcinoma cells. Treatment of either cell line resulted in the specifi...

Phase I study of oral CI-994 in combination with carboplatin and paclitaxel in the treatment of patients with advanced solid tumors.

Cancer Invest. 22(6) , 886-96, (2004)

To determine maximum tolerated dose of CI-994, a novel oral histone deacetylase inhibitor, in combination with carboplatin and paclitaxel in patients with advanced solid tumors.Patients with advanced ...

Cytotoxic chemotherapy regimens that increase dose per cycle (dose intensity) by extending daily dosing from 5 consecutive days to 28 consecutive days and beyond.

Clin. Cancer Res. 6(6) , 2474-81, (2000)

Dose intensity, defined as dose administered per unit time, has emerged as a potentially important measurement of anticancer drug exposure and determinant of efficacy. There are several strategies for...