Raltitrexed

Suppliers

Names

[ CAS No. ]:
112887-68-0

[ Name ]:
Raltitrexed

[Synonym ]:
N-[5-[N-[(3,4-dihydro-2-methyl-4-oxy-6-quinazolinyl)-methyl]-N-methylamino]-2-thenoyl]-L-glutamic acid
2kce
ZD1694
L-Glutamic acid, N-[[5-[[(1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]-
N-[(5-{methyl[(2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl]amino}thiophen-2-yl)carbonyl]-L-glutamic acid
N-[(5-{Methyl[(2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl]amino}-2-thienyl)carbonyl]-L-glutamic acid
Raltitrexed
D1694
ICI-D 1694
MFCD00864168
N-(5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl)-L-glutamic acid
Tomudex
2tsr
N-[[5-[[(1,4-Dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]-L-glutamic acid
ICI D1694
N-[(5-{Methyl[(2-methyl-4-oxo-1,4-dihydro-6-quinazolinyl)methyl]amino}-2-thienyl)carbonyl]-L-glutamic acid

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Melting Point ]:
176-1800C

[ Molecular Formula ]:
C21H22N4O6S

[ Molecular Weight ]:
458.488

[ Exact Mass ]:
458.126007

[ PSA ]:
180.93000

[ LogP ]:
-1.28

[ Index of Refraction ]:
1.692

[ Storage condition ]:
Hygroscopic, -20°C Freezer, Under Inert Atmosphere

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/38

[ Safety Phrases ]:
S26-S36/37/39-S45-S25

[ RIDADR ]:
UN 3265 8/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
II

[ Hazard Class ]:
8

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Diethyl N-[5-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-methylamino]-2-thenoyl]-L-glutamate
  • 6-(Bromomethyl)-2-methyl-4(1H)-quinazolinone
  • Diethyl N-[5-methylamino-2-thenoyl]-L-glutamate
  • 5-Nitrothiophene-2-carbonyl Chloride
  • H-Glu(OEt)-OEt.HCl
  • 5-[N-(tert-butoxycarbonyl)-N-methylamino]-2-thiophenecarboxylic acid
  • diethyl N-(5-nitro-2-thienoyl)-L-glutamate

DownStream

Related Compounds

  • N-(3-fluorophenyl)-2-((5-(4-methoxyphenyl)-1-methyl-1H-imidazol-2-yl)thio)acetamide
  • N-(2-methoxybenzyl)-2-((5-(4-methoxyphenyl)-1-methyl-1H-imidazol-2-yl)thio)acetamide
  • N-(4-methoxyphenethyl)-2-((5-(4-methoxyphenyl)-1-methyl-1H-imidazol-2-yl)thio)acetamide
  • N-(3,5-dimethoxyphenyl)-2-((5-(4-methoxyphenyl)-1-methyl-1H-imidazol-2-yl)thio)acetamide
  • N-Butyl-2,3-dihydro-1H-inden-1-amine
  • 2-[1-(2-chloroquinolin-4-yl)-N-ethylformamido]-N-[(thiophen-2-yl)methyl]acetamide
  • [(4-Methyl-3-nitrophenyl)carbamoyl]methyl 2,6-dichloropyridine-4-carboxylate
  • N-(1-cyanocyclohexyl)-2-(2-methyl-2,3-dihydro-1H-indol-1-yl)acetamide
  • 1-(5-Methylfuran-2-yl)prop-2-en-1-one
  • 1-Naphthalenol, 2-ethyl-1,2-dihydro-, (1S,2S)-
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