UCN-01

Suppliers

Names

[ CAS No. ]:
112953-11-4

[ Name ]:
UCN-01

[Synonym ]:
UCN-01
1okz

Chemical & Physical Properties

[ Density]:
1.63g/cm3

[ Boiling Point ]:
705.7ºC at 760mmHg

[ Molecular Formula ]:
C28H26N4O4

[ Molecular Weight ]:
482.53000

[ Flash Point ]:
380.6ºC

[ Exact Mass ]:
482.19500

[ PSA ]:
89.68000

[ LogP ]:
4.56460

[ Vapour Pressure ]:
6.64E-21mmHg at 25°C

[ Index of Refraction ]:
1.827

[ Storage condition ]:
-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KC6600010
CAS REGISTRY NUMBER :
112953-11-4
LAST UPDATED :
199312
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C28-H26-N4-O4
MOLECULAR WEIGHT :
482.58

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 42,571,1989

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
KC6600010

Articles

Nitric oxide donors increase PVR/CD155 DNAM-1 ligand expression in multiple myeloma cells: role of DNA damage response activation.

BMC Cancer 15 , 17, (2015)

DNAX accessory molecule-1 (DNAM-1) is an activating receptor constitutively expressed by macrophages/dendritic cells and by T lymphocytes and Natural Killer (NK) cells, having an important role in ant...

Induction of DNA damage and G2 cell cycle arrest by diepoxybutane through the activation of the Chk1-dependent pathway in mouse germ cells.

Chem. Res. Toxicol. 28(3) , 518-31, (2015)

1,2:3,4-Diepoxybutane (DEB) is a major carcinogenic metabolite of 1,3-butadiene (BD), which has been shown to cause DNA strand breaks in cells through its potential genotoxicity. The adverse effect of...

The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux.

Autophagy 11 , 1373-88, (2015)

Oncogenic mutation of KRAS (Kirsten rat sarcoma viral oncogene homolog) in colorectal cancer (CRC) confers resistance to both chemotherapy and EGFR (epidermal growth factor receptor)-targeted therapy....


More Articles

Related Compounds

  • Ucn-01-Me
  • UCN-02
  • HJ-01
  • CCC07-01
  • HA 01-0196
  • HTH 01-015
  • 9V8Ufq35Q9
  • 2-[3-(3-methoxyphenyl)-6-oxopyridazin-1(6H)-yl]-N-[(2Z)-4-(pyridin-4-yl)-1,3-thiazol-2(3H)-ylidene]acetamide
  • 8-(Pyridin-4-yl)-2-azaspiro[4.5]decane
  • 2-Oxo-2-(5,6,7,8-tetrahydronaphthalen-1-yl)acetic acid
  • 2-chloro-1-methyl-5-(1-methyl-1H-pyrazol-5-yl)-1H-pyrrole-3-carboxylic acid
  • Benzyl 1-(cyclohexanecarboxamido)cyclohexane-1-carboxylate
  • methyl 5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepine-2-carboxylate
  • 3-(3-Bromophenyl)-6-({[3-(3,5-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}thio)pyridazine
  • 2,2-Dimethyl-3-(3-methylcyclohexyl)propanal
  • 4-[1-(3-Amino-4-methoxy-benzoyl)-4-piperidyl]benzonitrile