PD128907 HCl

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Names

[ CAS No. ]:
112960-16-4

[ Name ]:
PD128907 HCl

[Synonym ]:
(+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride
S(+)-PD 128,907 hydrochloride
PD 125,530
R(-)-PD 128,908 hydrochloride
S(+)-(4aR,10bR)-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride
(+)-PD 128,907 hydrochloride

Chemical & Physical Properties

[ Melting Point ]:
145-153°C

[ Molecular Formula ]:
C14H20ClNO3

[ Molecular Weight ]:
285.77

[ Exact Mass ]:
285.11300

[ PSA ]:
41.93000

[ LogP ]:
2.67640

[ Appearance of Characters ]:
white

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
H2O: >5mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Articles

Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907.

J. Pharmacol. Exp. Ther. 275 , 1355, (1995)

The present study determined the biochemical and pharmacological effects of PD 128907 [R-(+)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H- [1]benzopyrano[4,3-b]-1,4-oxazin-9-ol], a dopamine (DA) recepto...

Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers.

J. Med. Chem. 33 , 445-450, (1990)

The dopamine agonist profile of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol (16a) and its enantiomers (16b-c) was examined. Racemic 16a exhibited moderate af...

Dopamine D3 (auto) receptors inhibit dopamine release in the frontal cortex of freely moving rats in vivo.

J. Neurochem. 66 , 2209, (1996)

In freely moving rats, the novel, selective dopamine (DA) D3 receptor agonist PD 128,907 dose-dependently [effective dose (ED25) = 0.07 mg/kg, s.c.] reduced dialysate levels of DA in the frontal corte...


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