guanidine

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Names

[ CAS No. ]:
113-00-8

[ Name ]:
guanidine

[Synonym ]:
Imidourea
amino-amidine
Aminoformamidine
Carbamidine
Iminourea
EINECS 204-021-8
guanidino acid
Guanidin
Aminomethanamidine
Carbamamidine

Chemical & Physical Properties

[ Density]:
1.55g/cm3

[ Boiling Point ]:
132.9ºC at 760mmHg

[ Molecular Formula ]:
CH5N3

[ Molecular Weight ]:
59.07050

[ Flash Point ]:
34.2ºC

[ Exact Mass ]:
59.04830

[ PSA ]:
75.89000

[ LogP ]:
0.33890

[ Vapour Pressure ]:
8.67mmHg at 25°C

[ Index of Refraction ]:
1.595

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ME7750000
CHEMICAL NAME :
Guanidine
CAS REGISTRY NUMBER :
113-00-8
BEILSTEIN REFERENCE NO. :
0506044
LAST UPDATED :
199709
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C-H5-N3
MOLECULAR WEIGHT :
59.09
WISWESSER LINE NOTATION :
ZYZUM

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1352,1935
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956- Volume(issue)/page/year: 61,291,1966
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
266 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1352,1935
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,718,1989
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1352,1935 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6654 No. of Facilities: 78 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 465 (estimated) No. of Female Employees: 78 (estimated)

Safety Information

[ RIDADR ]:
UN 1759

[ Packaging Group ]:
II

Synthetic Route

Precursor & DownStream

Precursor

  • Guanidine hydrochloride
  • Cyanamide
  • N-Ethylbutylamine
  • Urea
  • 3-Benzyloxyaniline
  • Amidinothiourea
  • 2-chloro-3-oxobutanoic acid

DownStream

  • Sulfaguanidine
  • Carbonic acid-guanidine (1:2)
  • Urea
  • Nitroguanidine
  • 2-Aminopyrimidine-4,6-diol
  • 2-Amino-6-hydroxy-4-methylpyrimidine
  • 2-Guanidinoacetic acid
  • 4-methylsulfanyl-6-phenyl-1,3,5-triazin-2-amine
  • 4(3H)-Pyrimidinone,2-amino-5,6-dihydro-
  • 1,3,5-Triazine-2,4-diamine

Related Compounds

  • guanidine
  • guanidine
  • guanidine
  • Guanidine
  • guanidine,4
  • Biguanidine
  • 2-[5-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pentanamido]-3,3,3-trifluoro-2-methylpropanoic acid
  • (2S)-2-{2-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)piperidin-1-yl]acetamido}-3-hydroxypropanoic acid
  • 2-[2-ethyl-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-N-(2-methylpropyl)butanamido]acetic acid
  • 3,3-Dimethyl-1-[(5-methylpyridin-3-yl)sulfanyl]pentan-2-one
  • (3-Amino-1H-indol-5-yl)dimethylphosphine oxide
  • 3-cyclopropyl-3-{[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}butanoic acid
  • 3-cyclopropyl-3-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylbutanamido]butanoic acid
  • 2-{[3-cyclopropyl-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]methyl}butanoic acid
  • (2R)-2-[3-cyclopropyl-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]-3-methylbutanoic acid
  • 4-[3-cyclopropyl-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]-2-methylbutanoic acid
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