Chlorpheniramine maleate

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Names

[ CAS No. ]:
113-92-8

[ Name ]:
Chlorpheniramine maleate

[Synonym ]:
teldrin
CHLORPHENAMINE MALEATES
BISACODYL
Chlorphenamine Maleate
3-(4-chlorophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine
2-[p-Chloro-a-(2-dimethylaminoethyl)benzyl]pyridine
CHLOROPHENAMINEMALEATE
CHLORPHENIRAMINE-D4 MALEATE
ChlorpheniramineMaleate
alunex
Cloropiril
M.P. chlorcaps T.D.
Chlorpheniramine (maleate)
Haynon
3-(4-Chlorophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine (2Z)-2-butenedioate (1:1)
CHLORPHENAMINE HYDROGEN MALEATE, WHO STANDARD
EINECS 205-054-0
(±)-Chlorpheniramine maleate
UNII:V1Q0O9OJ9Z
Allergisan
(±)-Chlorpheniramine
3-(4-Chlorophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine
Chlortrimeton
2-pyridinepropanamine, g-(4-chlorophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1)
3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
piriex
Chloropheniramine maleate
piriton
P-CHLORO(2-DIMETHYLAMINOETHYL)BENZYLPYRIDINE MALEATE
d-chlorpheniramine maleate
D-2-(p-Chloro-α-(2-dimethylaminoethyl)benzyl)pyridine
(+/-)-CHLORPHENIRAMINE MALEATE SALT
dl-Chlorpheniramine
chlorpheniramine
(+/-)-CHLORPHENIRAMINE-D6 MALEATE
CHLORPHENIRAMINE HYDROGEN MALEATE
2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-
ibioton
2-Pyridinepropanamine
Histadur
c-meton
4-Chloropheniramine
Puermin
[3-(4-chlorophenyl)-3-(2-pyridyl)propyl]dimethylamine
MFCD00069225
3-(4-Chlorophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine (2Z)-but-2-enedioate (1:1)
2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1)
chlorphenamine
2-pyridinepropanamine, g-(4-chlorophenyl)-N,N-dimethyl-
Cloropiril M.P.
CHLORPHENIRAMINE MALEATE REFERENCE STANDARD
dexchlorpheniramine maleate
1-(N,N-Dimethylamino)-3-(p-chlorophenyl-3-a-pyridyl)propane Maleate
CHLORPROPHENPYRIDAMINE MALEATE
g-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine
Chlorpheniramine Maleate
lorphen
Chlorpheniramine Maleate Salt
Chlorcaps T.D.
allergin
g-(4-Chlorophenyl)-g-(2-pyridyl)propyldimethylamine

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
379.0±42.0 °C at 760 mmHg

[ Melting Point ]:
130-135 °C(lit.)

[ Molecular Formula ]:
C20H23ClN2O4

[ Molecular Weight ]:
390.861

[ Flash Point ]:
183.0±27.9 °C

[ Exact Mass ]:
390.134644

[ PSA ]:
90.73000

[ LogP ]:
3.39

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.565

[ Storage condition ]:
-20°C Freezer

[ Water Solubility ]:
1-5 G/100 ML AT 21 ºC

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
US6475000
CAS REGISTRY NUMBER :
113-92-8
LAST UPDATED :
199707
DATA ITEMS CITED :
22
MOLECULAR FORMULA :
C16-H19-Cl-N2.C4-H4-O4
MOLECULAR WEIGHT :
390.90
WISWESSER LINE NOTATION :
T6NJ BYR DG&2N1&1 &OV1U1VO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
306 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
365 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
130 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
76700 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
104 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
26100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
97600 ug/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
198 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
101 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
68 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - wild bird species
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1120 mg/kg/14D-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
600 mg/kg/16D-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
420 mg/kg
SEX/DURATION :
female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
4200 mg/kg
SEX/DURATION :
female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - abortion

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
125 mg/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-317,1986 *** REVIEWS *** TOXICOLOGY REVIEW JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO 63132) V.3- 1969- Volume(issue)/page/year: 12,27,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84323 No. of Facilities: 1601 (estimated) No. of Industries: 5 No. of Occupations: 12 No. of Employees: 7109 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84323 No. of Facilities: 771 (estimated) No. of Industries: 3 No. of Occupations: 19 No. of Employees: 14566 (estimated) No. of Female Employees: 10522 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic

[ Risk Phrases ]:
R25

[ Safety Phrases ]:
36/37/39-45

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
US6504000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2933399090

Precursor & DownStream

Precursor

DownStream

  • DexChlorpheniramine Maleate
  • (-)-CARVEOL

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Related Compounds

  • chlorpheniramine maleate
  • d-Chlorpheniramine maleate
  • l-Chlorpheniramine maleate
  • Desmethyl Chlorpheniramine Maleate Salt
  • Didesmethyl Chlorpheniramine Maleate Salt
  • Chlorpheniramine maleate mixture with codeine
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  • Pyridine, 2-(1H-imidazol-2-yl)-6-(1-methylethyl)-
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4-(3-Pyridyl)-3,5-difluoroaniline
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine