3-Methyl-1-phenyl-1H-pyrazol-5-amine

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Names

[ CAS No. ]:
1131-18-6

[ Name ]:
3-Methyl-1-phenyl-1H-pyrazol-5-amine

[Synonym ]:
5-methyl-2-phenylpyrazol-3-amine
1H-Pyrazol-5-amine, 3-methyl-1-phenyl-
5-AMINO-3-METHYL-1-PHENYLPYRAZOLE
MFCD00020727
T5NNJ AR& C1 EZ
3-Methyl-1-phenyl-1H-pyrazol-5-amine
EINECS 214-463-3

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
333.0±22.0 °C at 760 mmHg

[ Melting Point ]:
114-117 °C(lit.)

[ Molecular Formula ]:
C10H11N3

[ Molecular Weight ]:
173.214

[ Flash Point ]:
155.2±22.3 °C

[ Exact Mass ]:
173.095291

[ PSA ]:
43.84000

[ LogP ]:
1.96

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.625

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UQ4990000
CHEMICAL NAME :
1H-Pyrazole-5-amine, 3-methyl-1-phenyl-
CAS REGISTRY NUMBER :
1131-18-6
BEILSTEIN REFERENCE NO. :
0140666
LAST UPDATED :
199701
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C10-H11-N3
MOLECULAR WEIGHT :
173.24
WISWESSER LINE NOTATION :
T5NNJ AR& C1 EZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2500 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
REFERENCE :
LONZA# Personal Communication from LONZA Ltd., CH-4002, Basel, Switzerland Volume(issue)/page/year: 03FEB1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1300 mg/kg
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions Behavioral - changes in motor activity (specific assay)
REFERENCE :
LONZA# Personal Communication from LONZA Ltd., CH-4002, Basel, Switzerland Volume(issue)/page/year: 03FEB1981
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 27,295,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity
REFERENCE :
LONZA# Personal Communication from LONZA Ltd., CH-4002, Basel, Switzerland Volume(issue)/page/year: 03FEB1981

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UQ4990000

[ HS Code ]:
2933199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Phenylhydrazine
  • 3-iminobutyronitrile
  • 3-Oxobutanenitrile
  • 3-aminocrotononitrile
  • 1H-Pyrazole-4-carbonitrile,5-amino-3-methyl-1-phenyl-
  • Phenylhydrazine hydrochloride
  • 3-phenylhydrazono-butyronitrile
  • ethyl 5-amino-3-methyl-1-phenylpyrazole-4-carboxylate

DownStream

  • 3-methyl-1,5-diphenyl-2H-imidazo[4,5-c]pyrazole
  • 6-amino-3-methyl-4-(3-nitrophenyl)-1-phenylpyrazolo[3,4-b]pyridine-5-carbonitrile
  • (5-amino-3-methyl-1-phenylpyrazol-4-yl) thiocyanate
  • N'-(4-formyl-5-methyl-2-phenylpyrazol-3-yl)-N,N-dimethylmethanimidamide
  • 3-Methyl-1-phenyl-4-pyridin-3-yl-1H-indeno[1,2-b]pyrazolo[4,3-e]pyridin-5-one
  • 4-Ethyl-3-methyl-1-phenyl-1H-indeno[1,2-b]pyrazolo[4,3-e]pyridin-5-one
  • 4-(4-dimethylaminophenyl)-3-methyl-1-phenylindeno[2,1-e]pyrazolo[3,4-b]pyridine-5(1H)-one
  • 4-(4-CHLORO-PHENYL)-3-METHYL-1-PHENYL-1H-INDENO[1,2-B]PYRAZOLO[4,3-E]PYRIDIN-5-ONE
  • Acid Yellow 49
  • 1-(5-methyl-2-phenylpyrazol-3-yl)-3-phenylurea

Customs

[ HS Code ]: 2933199090

[ Summary ]:
2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Synthesis of Newly Substituted Pyrazoles and Substituted Pyrazolo [3, 4-b] Pyridines Based on 5-Amino-3-Methyl-1-Phenylpyrazole. El-Emary TI.

J. Chin. Chem. Soc. 54(2) , 507-518, (2007)

An unexpected chemical behavior of 5-N-(benzotriazol-1-ylmethyl) amino-3-tert-butyl-1-phenylpyrazole. Abonia R, et al.

Tetrahedron Lett. 43(22) , 5617-5620, (2002)

The synthesis of fused and pendant pyrazole heterocyclic compounds from 5-amino-3-methyl-1-phenylpyrazole and their evaluation as fluorescent brightening agents. Tagdiwala PV and Rangnekar DW.

J. Chem. Technol. Biotechnol. 38(2) , 77-84, (1987)


More Articles

Related Compounds

  • 4-bromo-3-methyl-1-phenyl-1H-pyrazol-5-amine
  • 4-chloro-3-methyl-1-phenyl-1H-pyrazol-5-amine
  • N,N-diethyl-3-methyl-1-phenyl-1H-pyrazol-5-amine
  • 4-[(2,4-dinitrophenyl)azo]-3-methyl-1-phenyl-1H-pyrazol-5-amine
  • 4-((2,5-Dichloro-4-sulfophenyl)azo)-3-methyl-1-phenyl-1H-pyrazol-5-amine monosodium salt
  • (3-methyl-1-phenyl-1H-pyrazol-5-yl) benzoate
  • O-[2-(2,4,5-trimethoxyphenyl)propyl]hydroxylamine
  • 4-(2-Fluoro-6-methoxyphenyl)oxane-2,6-dione
  • 2-Amino-3-methyl-3-(oxan-2-yl)butanoic acid
  • 2-Amino-3-[3-(dimethylamino)phenyl]-3-hydroxypropanoic acid
  • 2-Ethoxy-6-ethynylphenol
  • 2-[2-(1-Aminocyclopropyl)ethyl]-6-ethoxyphenol
  • 2-{[1-(Aminomethyl)cyclopropyl]methyl}-6-ethoxyphenol
  • 2-{1-[(Aminooxy)methyl]cyclopropyl}-6-ethoxyphenol
  • 5-(3-Nitrophenyl)-1,2-oxazol-4-amine
  • 3-(azetidin-2-yl)-5-methyl-1H-pyrazole
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