h-8 dihydrochloride

Names

[ CAS No. ]:
113276-94-1

[ Name ]:
h-8 dihydrochloride

[Synonym ]:
H-8 dihydrochloride
MFCD00036962

Chemical & Physical Properties

[ Boiling Point ]:
473.9ºC at 760 mmHg

[ Melting Point ]:
221-222℃ (methanol water )

[ Molecular Formula ]:
C₁₂H₁₇Cl₂N₃O₂S

[ Molecular Weight ]:
338.25300

[ Flash Point ]:
240.4ºC

[ Exact Mass ]:
337.04200

[ PSA ]:
79.47000

[ LogP ]:
4.19910

[ Vapour Pressure ]:
3.79E-09mmHg at 25°C

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
ethanol: 25 mg/mL, clear, colorless

MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

ISOQUINOLINE-5-SULFONYL CHLORIDE
2-[(5-Isoquinolinylsulfonyl)amino]ethyl 4-methylbenzenesulfonate
methylamine

DownStream

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Articles

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.

Biochemistry 23 , 5036-5041, (1984)

Naphthalenesulfonamides such as N-(6-amino-hexyl)-5-chloro-1-naphthalenesulfonamide (W-7) are potent calmodulin (CaM) antagonists and act upon several protein kinases at higher concentration. When the...

In vitro activation and nuclear translocation of NF-kappa B catalyzed by cyclic AMP-dependent protein kinase and protein kinase C.

Mol. Cell. Biol. 9 , 2424, (1989)

We have examined whether a precursor form of NF-kappa B, a DNA-binding protein that plays a role in the transcriptional control of several genes, including kappa immunoglobulin light chain and interle...

3-H-8-bromo-4-methyl-3,4-azabora-isochinoline
2-methyl-4-(7(9)H-[8-14C]purin-6-ylamino)-but-2-en-1-ol
dithiobenzoic acid
3,6-dimethyl-1H-pyrazin-2-one
N-Formyl-1,2,2,2-tetrachloroethylamine
3-(3-oxobutyl)-2-sulfanylideneimidazolidin-4-one
2-(3,4-dimethylphenyl)-3-(ethylthio)-N-(m-tolyl)-1,4,8-triazaspiro[4.5]deca-1,3-diene-8-carboxamide
N-(4-(4-methyl-5-oxo-4,5-dihydro-1H-tetrazol-1-yl)phenyl)-2-(naphthalen-1-yl)acetamide
N-(4-(4-methyl-5-oxo-4,5-dihydro-1H-tetrazol-1-yl)phenyl)-3-phenylpropanamide
N-(4-Bromo-3-methylphenyl)-2-methyloxolan-3-amine
1-(4-chlorophenyl)-N-[4-(4-methyl-5-oxo-4,5-dihydro-1H-1,2,3,4-tetrazol-1-yl)phenyl]cyclopentane-1-carboxamide
1-(3-methoxyphenyl)-N-(4-(4-methyl-5-oxo-4,5-dihydro-1H-tetrazol-1-yl)phenyl)-5-oxopyrrolidine-3-carboxamide
1-(4-fluorophenyl)-N-(4-(4-methyl-5-oxo-4,5-dihydro-1H-tetrazol-1-yl)phenyl)-5-oxopyrrolidine-3-carboxamide
4-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperazine-2-carboxylic acid hydrochloride
1-(4-chlorophenyl)-N-(4-(4-methyl-5-oxo-4,5-dihydro-1H-tetrazol-1-yl)phenyl)-5-oxopyrrolidine-3-carboxamide
2-(2-chlorophenyl)-N-(4-(4-methyl-5-oxo-4,5-dihydro-1H-tetrazol-1-yl)phenyl)acetamide

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