2,3,6-trifluorophenol

Names

[ Name ]:
2,3,6-trifluorophenol

[Synonym ]:
2,3,6-Trifluorophenol
2,3,4-TRI-O-BENZYL-Β-D-GLUCOPYRANOSIDURONIC ACID BENZYL ESTER,TRICHLOROACETIMIDATE
Phenol,2,3,6-trifluoro-(9CI)
2,3,6-trifluoro-phenol
MFCD00061214

Chemical & Physical Properties

[ Density]:
1.473g/cm3

[ Boiling Point ]:
137ºC at 760mmHg

[ Melting Point ]:
33-37 °C(lit.)

[ Molecular Formula ]:
C₆H₃F₃O

[ Molecular Weight ]:
148.08300

[ Flash Point ]:
147 °F

[ Exact Mass ]:
148.01400

[ PSA ]:
20.23000

[ LogP ]:
1.80950

[ Vapour Pressure ]:
5.81mmHg at 25°C

[ Index of Refraction ]:
1.471

MSDS

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H228-H302-H312-H315-H319-H332-H335

[ Precautionary Statements ]:
P210-P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn,Xi:Irritant;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S26-S36/37/39

[ RIDADR ]:
UN 1325 4.1/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
4.1

[ HS Code ]:
2908199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2,3,5-trifluoro-4-hydroxybenzoic acid
tetrafluorobenzene

DownStream

4-bromo-2,3,6-trifluorophenol
(2S)-2-amino-3-(2,3,5-trifluoro-4-hydroxyphenyl)propanoic acid
2,4,5-Trifluoro-3-hydroxybenzoic acid

Customs

[ HS Code ]: 2908199090

[ Summary ]:
HS: 2908199090. derivatives of polyphenols or phenol-alcohols containing only halogen substituents and their salts. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:None. MFN tariff:5.5%. general tariff:30.0%

Articles

19F NMR metabolomics for the elucidation of microbial degradation pathways of fluorophenols.

J. Ind. Microbiol. Biotechnol. 26(1-2) , 22-34, (2001)

Of all NMR-observable isotopes 19F is the one most convenient for studies on the biodegradation of environmental pollutants and especially for fast initial metabolic screening of newly isolated organi...

The site-selective functionalization of halogen-bearing phenols: an exercise in diversity-oriented organometallic synthesis. Marzi E and Schlosser M.

Tetrahedron 61(13) , 3393-3401, (2005)

4-amino-2,3,6-trifluorophenol
4-bromo-2,3,6-trifluorophenol
2,3-dichloro-4,5,6-trifluorophenol
(2,3,6-Trifluoro-4-pyridinyl)methanol
2,3,6-trichloro-4-(3,5-dichloro-4-hydroxyphenyl)phenol
2-[3-[6-[3-(oxan-2-yloxy)prop-1-ynyl]pyren-1-yl]prop-2-ynoxy]oxane
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
(5-(Methylthio)pyridin-2-yl)methanol
tert-Butyl-DL-alanine
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide