PNU 74654

Suppliers

Names

[ Name ]:
PNU 74654

[Synonym ]:
Benzoic acid, 2-phenoxy-, 2-[(1E)-(5-methyl-2-furanyl)methylene]hydrazide
N'-[(E)-(5-Methyl-2-furyl)methylene]-2-phenoxybenzohydrazide
N'-[(E)-(5-methylfuran-2-yl)methylidene]-2-phenoxybenzohydrazide
PNU-74654

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Molecular Formula ]:
C₁₉H₁₆N₂O₃

[ Molecular Weight ]:
320.342

[ Exact Mass ]:
320.116089

[ PSA ]:
63.83000

[ LogP ]:
3.90

[ Index of Refraction ]:
1.593

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ RIDADR ]:
NONH for all modes of transport

Articles

An increase in glucosylceramide synthase induces Bcl-xL-mediated cell survival in vinorelbine-resistant lung adenocarcinoma cells.

Oncotarget 6 , 20513-24, (2015)

Reversing drug resistance with concurrent treatment confers anticancer benefits. In this study, we investigated the potential mechanism of glucosylceramide synthase (GCS)-mediated vinca alkaloid vinor...

The WTX Tumor Suppressor Interacts with the Transcriptional Corepressor TRIM28.

J. Biol. Chem. 290 , 14381-90, (2015)

WTX encodes a tumor suppressor implicated in the pediatric kidney cancer Wilms tumor and in mesenchymal differentiation with potentially distinct functions in the cytoplasm, at the plasma membrane, an...

Inhibition of the Tcf/beta-catenin complex increases apoptosis and impairs adrenocortical tumor cell proliferation and adrenal steroidogenesis.

.PubMed ID

To date, there is no effective therapy for patients with advanced/metastatic adrenocortical cancer (ACC). The activation of the Wnt/beta-catenin signaling is frequent in ACC and this pathway is a prom...