Cabozantinib malate (XL184)

Suppliers

Names

[ CAS No. ]:
1140909-48-3

[ Name ]:
Cabozantinib malate (XL184)

[Synonym ]:
Cabozantinib malate (XL184)
Cometriq
UNII-DR7ST46X58
N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (L) malate
N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (L)-malate salt
XL 184
Cabozantinib L-Malate Salt
Butanedioic acid, 2-hydroxy-, (2S)-, compd. with N-[4-[(6,7-dimethoxy-4- quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)
Butanedioic acid, 2-hydroxy-, (2S)-, compd. with N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)
cabozantinib malate
Cabozantinib (XL184)
N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide mono[(2S)-2-hydroxybutanedioate]
UNII:DR7ST46X58
Cabozantinib s-malate
(2S)-2-Hydroxysuccinic acid - N-{4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl}-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)
Cabozantinib s-malate [USAN]
Cabozantinib malate salt
cyclopropane-1,1-dicarboxylic acid [4-(6,7-dimethoxy-quinoline-4-yloxy)-phenyl]-amide (4-fluoro-phenyl)-amide L-malate
cyclopropane-1,1-dicarboxylic acid [4-(6,7-dimethoxyquinoline-4-yloxy)phenyl]amide (4-fluoro-phenyl)amide (L)-malate salt
cabozantinib L-malate
Cabozantinib (S-malate)

Chemical & Physical Properties

[ Molecular Formula ]:
C32H30FN3O10

[ Molecular Weight ]:
635.593

[ Exact Mass ]:
635.191528

[ PSA ]:
193.61000

[ LogP ]:
4.59340

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Precursor & DownStream

Precursor

  • L-(-)-Malic acid
  • Cabozantinib (XL184, BMS-907351)
  • 4-Hydroxy-6,7-dimethoxyquinoline
  • 4-Chloro-6,7-dimethoxyquinoline
  • Cyclopropane-1,1-dicarboxylic acid
  • 4-Fluoroaniline
  • 1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid

DownStream


Related Compounds

  • Cabozantinib (XL184, BMS-907351)
  • Cabozantinib-d6
  • Cabozantinib Impurity 14
  • Cabozantinib hydrochloride
  • Cabozantinib-d4
  • Cabozantinib Impurity 11
  • 2-{1-[(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(1H-imidazol-4-yl)propanamido]cyclopropyl}acetic acid
  • (3S)-3-{[(tert-butoxy)carbonyl]amino}-3-(3-ethoxy-4-methoxyphenyl)propanoic acid
  • (3S)-3-{[(tert-butoxy)carbonyl]amino}-3-(3-chloro-4,5-dimethoxyphenyl)propanoic acid
  • (3S)-3-{[(tert-butoxy)carbonyl]amino}-3-[2-chloro-5-(trifluoromethyl)phenyl]propanoic acid
  • 1-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)but-2-ynoyl]-2-propylpyrrolidine-2-carboxylic acid
  • 4-{[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methyloxolan-3-yl]formamido}but-2-ynoic acid
  • 4-{2-ethyl-2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]butanamido}but-2-ynoic acid
  • 4-{[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-5-methylphenyl]formamido}but-2-ynoic acid
  • 4-{[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-methylphenyl]formamido}but-2-ynoic acid
  • 4-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)but-2-ynoyl]thiomorpholine-3-carboxylic acid