Cabozantinib malate (XL184)

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Names

[ CAS No. ]:
1140909-48-3

[ Name ]:
Cabozantinib malate (XL184)

[Synonym ]:
Cabozantinib malate (XL184)
Cometriq
UNII-DR7ST46X58
N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (L) malate
N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (L)-malate salt
XL 184
Cabozantinib L-Malate Salt
Butanedioic acid, 2-hydroxy-, (2S)-, compd. with N-[4-[(6,7-dimethoxy-4- quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)
Butanedioic acid, 2-hydroxy-, (2S)-, compd. with N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)
cabozantinib malate
Cabozantinib (XL184)
N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide mono[(2S)-2-hydroxybutanedioate]
UNII:DR7ST46X58
Cabozantinib s-malate
(2S)-2-Hydroxysuccinic acid - N-{4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl}-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)
Cabozantinib s-malate [USAN]
Cabozantinib malate salt
cyclopropane-1,1-dicarboxylic acid [4-(6,7-dimethoxy-quinoline-4-yloxy)-phenyl]-amide (4-fluoro-phenyl)-amide L-malate
cyclopropane-1,1-dicarboxylic acid [4-(6,7-dimethoxyquinoline-4-yloxy)phenyl]amide (4-fluoro-phenyl)amide (L)-malate salt
cabozantinib L-malate
Cabozantinib (S-malate)

Chemical & Physical Properties

[ Molecular Formula ]:
C32H30FN3O10

[ Molecular Weight ]:
635.593

[ Exact Mass ]:
635.191528

[ PSA ]:
193.61000

[ LogP ]:
4.59340

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • L-(-)-Malic acid
  • Cabozantinib (XL184, BMS-907351)
  • 4-Hydroxy-6,7-dimethoxyquinoline
  • 4-Chloro-6,7-dimethoxyquinoline
  • Cyclopropane-1,1-dicarboxylic acid
  • 4-Fluoroaniline
  • 1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid

DownStream

Related Compounds

  • Cabozantinib (XL184, BMS-907351)
  • Cabozantinib-d6
  • Cabozantinib Impurity 14
  • Cabozantinib hydrochloride
  • Cabozantinib-d4
  • Cabozantinib Impurity 11
  • [[5-(Trifluoromethyl)furan-2-yl]methylideneamino]thiourea
  • Formamide, N,N-dimethyl-, azine with o-anisaldehyde
  • 2-amino-2-(4,5,6,7-tetrahydro-1H-indol-2-yl)ethan-1-ol
  • 3,4-Dimethoxy-I+/--[(4-methyl-1-piperazinyl)methylene]benzeneacetaldehyde
  • 2-(1-Benzofuran-2-yl)-2-oxoethyl 1-chloroisoquinoline-3-carboxylate
  • 2-(2,4-dioxo-3-propyl-4aH-thieno[3,2-d]pyrimidin-1-ium-1-yl)-N-(furan-2-ylmethyl)acetamide
  • 3-Ethenyl-1,5-dihydro-4-methyl-5-(phenylmethylene)-2H-pyrrol-2-one
  • N-[2-(cyclohexen-1-yl)ethyl]-2-(2,4-dioxo-3-propyl-4aH-thieno[3,2-d]pyrimidin-1-ium-1-yl)acetamide
  • 2-(2,4-dioxo-3-propyl-4aH-thieno[3,2-d]pyrimidin-1-ium-1-yl)-N-[(4-methylphenyl)methyl]acetamide
  • N-(1,3-benzodioxol-5-yl)-2-(2,4-dioxo-3-propyl-4aH-thieno[3,2-d]pyrimidin-1-ium-1-yl)acetamide
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