Cabozantinib malate (XL184)

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Names

[ CAS No. ]:
1140909-48-3

[ Name ]:
Cabozantinib malate (XL184)

[Synonym ]:
Cabozantinib malate (XL184)
Cometriq
UNII-DR7ST46X58
N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (L) malate
N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (L)-malate salt
XL 184
Cabozantinib L-Malate Salt
Butanedioic acid, 2-hydroxy-, (2S)-, compd. with N-[4-[(6,7-dimethoxy-4- quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)
Butanedioic acid, 2-hydroxy-, (2S)-, compd. with N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)
cabozantinib malate
Cabozantinib (XL184)
N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide mono[(2S)-2-hydroxybutanedioate]
UNII:DR7ST46X58
Cabozantinib s-malate
(2S)-2-Hydroxysuccinic acid - N-{4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl}-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)
Cabozantinib s-malate [USAN]
Cabozantinib malate salt
cyclopropane-1,1-dicarboxylic acid [4-(6,7-dimethoxy-quinoline-4-yloxy)-phenyl]-amide (4-fluoro-phenyl)-amide L-malate
cyclopropane-1,1-dicarboxylic acid [4-(6,7-dimethoxyquinoline-4-yloxy)phenyl]amide (4-fluoro-phenyl)amide (L)-malate salt
cabozantinib L-malate
Cabozantinib (S-malate)

Chemical & Physical Properties

[ Molecular Formula ]:
C32H30FN3O10

[ Molecular Weight ]:
635.593

[ Exact Mass ]:
635.191528

[ PSA ]:
193.61000

[ LogP ]:
4.59340

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • L-(-)-Malic acid
  • Cabozantinib (XL184, BMS-907351)
  • 4-Hydroxy-6,7-dimethoxyquinoline
  • 4-Chloro-6,7-dimethoxyquinoline
  • Cyclopropane-1,1-dicarboxylic acid
  • 4-Fluoroaniline
  • 1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid

DownStream

Related Compounds

  • Cabozantinib (XL184, BMS-907351)
  • Cabozantinib-d6
  • Cabozantinib Impurity 14
  • Cabozantinib hydrochloride
  • Cabozantinib-d4
  • Cabozantinib Impurity 11
  • tert-butyl N-{4-[1-(aminomethyl)-3,3-difluorocyclobutyl]phenyl}carbamate
  • 3-(2-Chloro-6-methylpyridin-3-yl)-2,2-dimethylcyclopropane-1-carboxylic acid
  • 1-[2-(5-Bromothiophen-3-yl)propan-2-yl]cyclopropan-1-amine
  • 4-Bromo-3-[1-(hydroxymethyl)cyclopropyl]benzonitrile
  • tert-butyl N-[1-amino-3-(1,5-dimethyl-1H-pyrazol-4-yl)propan-2-yl]carbamate
  • methyl 4-amino-3-[(1S,5S)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl]butanoate
  • 2-methyl-2-(4,5,6,7-tetrahydro-1H-indazol-3-yl)propan-1-ol
  • tert-butyl N-[4-(2-amino-1,3-oxazol-5-yl)-2-methylphenyl]carbamate
  • 2,2-difluoro-2-{3H-[1,2,3]triazolo[4,5-b]pyridin-6-yl}ethan-1-ol
  • 3-(Aminomethyl)-3-(2,3-dihydro-1-benzofuran-7-yl)cyclobutan-1-ol
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