Cabozantinib malate (XL184)

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Names

[ CAS No. ]:
1140909-48-3

[ Name ]:
Cabozantinib malate (XL184)

[Synonym ]:
Cabozantinib malate (XL184)
Cometriq
UNII-DR7ST46X58
N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (L) malate
N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (L)-malate salt
XL 184
Cabozantinib L-Malate Salt
Butanedioic acid, 2-hydroxy-, (2S)-, compd. with N-[4-[(6,7-dimethoxy-4- quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)
Butanedioic acid, 2-hydroxy-, (2S)-, compd. with N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)
cabozantinib malate
Cabozantinib (XL184)
N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide mono[(2S)-2-hydroxybutanedioate]
UNII:DR7ST46X58
Cabozantinib s-malate
(2S)-2-Hydroxysuccinic acid - N-{4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl}-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)
Cabozantinib s-malate [USAN]
Cabozantinib malate salt
cyclopropane-1,1-dicarboxylic acid [4-(6,7-dimethoxy-quinoline-4-yloxy)-phenyl]-amide (4-fluoro-phenyl)-amide L-malate
cyclopropane-1,1-dicarboxylic acid [4-(6,7-dimethoxyquinoline-4-yloxy)phenyl]amide (4-fluoro-phenyl)amide (L)-malate salt
cabozantinib L-malate
Cabozantinib (S-malate)

Chemical & Physical Properties

[ Molecular Formula ]:
C32H30FN3O10

[ Molecular Weight ]:
635.593

[ Exact Mass ]:
635.191528

[ PSA ]:
193.61000

[ LogP ]:
4.59340

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • L-(-)-Malic acid
  • Cabozantinib (XL184, BMS-907351)
  • 4-Hydroxy-6,7-dimethoxyquinoline
  • 4-Chloro-6,7-dimethoxyquinoline
  • Cyclopropane-1,1-dicarboxylic acid
  • 4-Fluoroaniline
  • 1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid

DownStream

Related Compounds

  • Cabozantinib (XL184, BMS-907351)
  • Cabozantinib-d6
  • Cabozantinib Impurity 14
  • Cabozantinib hydrochloride
  • Cabozantinib-d4
  • Cabozantinib Impurity 11
  • 3-(5-Bromo-2-fluorophenyl)-2,6-difluoroaniline
  • (1R)-1-(4-bromo-1-benzofuran-2-yl)-3-methylbutan-1-amine
  • 1-[4-(6-Chloro-5-fluoro-2-methylpyrimidin-4-yl)piperazin-1-yl]ethan-1-one
  • Methyl 3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-4-carboxylate
  • alpha-Hydroxymetoprolol-d7 (iso-propyl-d7) (mixture of stereoisomers)
  • Thalidomide-NH-amido-C3-NH2
  • Dimethoxy-1,2-thiazole-4-carboxamide
  • 2-(5-Amino-3-methyl-1H-pyrazol-1-yl)-6-(trifluoromethyl)pyrimidin-4(3H)-one
  • 1-(4-Methoxy-3-nitrophenyl)-2-(methylamino)ethan-1-one
  • 3-(Pent-4-en-2-yl)oxane-3-carbaldehyde
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