PD 128042

Names

[ CAS No. ]:
114289-47-3

[ Name ]:
PD 128042

[Synonym ]:
CI 976
2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
C23H39NO4

Chemical & Physical Properties

[ Density]:
1.002g/cm3

[ Boiling Point ]:
504.7ºC at 760mmHg

[ Molecular Formula ]:
C₂₃H₃₉NO₄

[ Molecular Weight ]:
393.56000

[ Flash Point ]:
259ºC

[ Exact Mass ]:
393.28800

[ PSA ]:
56.79000

[ LogP ]:
6.28090

[ Vapour Pressure ]:
2.59E-10mmHg at 25°C

[ Index of Refraction ]:
1.503

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JR2052000

CHEMICAL NAME :: Dodecanamide, 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)-

CAS REGISTRY NUMBER :: 114289-47-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C23-H39-N-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 157 gm/kg/56W-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 13,317,1993

Safety Information

[ Hazard Statements ]:
H413

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2924299090

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

cPLA2α and EHD1 interact and regulate the vesiculation of cholesterol-rich, GPI-anchored, protein-containing endosomes.

Mol. Biol. Cell 23(10) , 1874-88, (2012)

The lipid modifier phospholipase A2 catalyzes the hydrolysis of phospholipids to inverted-cone-shaped lysophospholipids that contribute to membrane curvature and/or tubulation. Conflicting findings ex...

Use of acyltransferase inhibitors to block vesicular traffic between the ER and Golgi complex.

Meth. Enzymol. 404 , 115-25, (2005)

This article describes the use of acyltransferase inhibitors as probes for studying the potential role of lysophospholipid acyltransferases (LPAT) in intracellular membrane trafficking in the secretor...

A unique lysophospholipid acyltransferase (LPAT) antagonist, CI-976, affects secretory and endocytic membrane trafficking pathways.

J. Cell Sci. 118(Pt 14) , 3061-71, (2005)

Previous studies have shown that inhibition of a Golgi-complex-associated lysophospholipid acyltransferase (LPAT) activity by the drug CI-976 stimulates Golgi tubule formation and subsequent redistrib...