N-Cbz-glycine Ethyl Ester

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Names

[ CAS No. ]:
1145-81-9

[ Name ]:
N-Cbz-glycine Ethyl Ester

[Synonym ]:
Ethyl 2-(((benzyloxy)carbonyl)amino)acetate
ethyl 2-(phenylmethoxycarbonylamino)acetate
Z-Gly-Gly-Oet

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
502.1±40.0 °C at 760 mmHg

[ Melting Point ]:
81-82℃

[ Molecular Formula ]:
C14H18N2O5

[ Molecular Weight ]:
294.303

[ Flash Point ]:
257.4±27.3 °C

[ Exact Mass ]:
294.121582

[ PSA ]:
93.73000

[ LogP ]:
1.42

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.524

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MB9134000
CHEMICAL NAME :
Glycine, N-carboxy-, N-benzyl ester, ethyl ester
CAS REGISTRY NUMBER :
1145-81-9
BEILSTEIN REFERENCE NO. :
2219244
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C12-H15-N-O4
MOLECULAR WEIGHT :
237.28
WISWESSER LINE NOTATION :
2OV1MVO1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravaginal
DOSE :
280 mg/kg
SEX/DURATION :
female 28 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 70,60,1981

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-CARBETHOXYIMIDAZOLE
  • Z-Gly-OH
  • Benzyl chloroformate
  • Ethyl glycinate
  • Glycine ethyl ester hydrochloride
  • Ethanol
  • Z-Gly-NHNHPh
  • Tosyl chloride

DownStream

  • z-gly-nh2
  • Ethyl glycinate
  • L-Phenylalanine,N-[N-[(phenylmethoxy)carbonyl]glycyl]-, hydrazide (9CI)
  • Ethyl N-Cbz-4-Oxopyrrolidine-3-carboxylate
  • 2-Methylaminoethanol
  • Benzyl alcohol
  • Z-Gly-OH
  • Z-Gly-Ala-OH
  • Benzyl (2-oxoethyl)carbamate
  • benzyl N-(2-hydroxyethylcarbamoylmethyl)carbamate

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

  • N-CBZ-L-tyrosylglycine ethyl ester
  • N-(carbobenzyloxy)-L-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine ethyl ester
  • N-Cbz-threonine ethyl ester
  • N-(thiobenzoyl)glycine ethyl ester
  • N-(diphenylmethylene)glycine ethyl ester
  • N-palmitoyl-glycine ethyl ester
  • (2S)-1-(2,3,4-trimethoxyphenyl)propan-2-ol
  • 4-(3,3-Dimethylpentyl)pyrrolidin-3-ol
  • 3-(2-Methylpropyl)-2-(pyrrolidin-3-yloxy)pyridine
  • 3-(2-Cyclopropylethynyl)-2-(pyrrolidin-3-yloxy)pyridine
  • 5-[2-(Pyrrolidin-3-yloxy)pyridin-3-yl]pent-4-yn-1-ol
  • Methyl 3-[2-(pyrrolidin-3-yloxy)pyridin-3-yl]prop-2-ynoate
  • 2-(Pyrrolidin-3-yloxy)-3-(thiophen-2-yl)pyrazine
  • 2-(Pyridin-3-yl)-3-(pyrrolidin-3-yloxy)pyrazine
  • 2-Cyclopropyl-3-(pyrrolidin-3-yloxy)pyrazine
  • 2-Phenyl-3-(pyrrolidin-3-yloxy)pyrazine
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