Losartan
Suppliers
Names
[ CAS No. ]:
114798-26-4
[ Name ]:
Losartan
[Synonym ]:
2-Butyl-4-chloro-1-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]imidazole-5-methanol
nyl)-4-yl)methyl)
1H-imidazole-5-methanol, 2-butyl-4-chloro-1-2'-(1H-tetrazol-5-yl)1,1'-biphenyl-4-ylmethyl-
Lorzaar
Compound 89
(2-Butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol
1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
LOS
2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol
(2-butyl-4-chloro-1-{2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl}-1H-imidazol-5-yl)methanol
Losartan
dup89
(2-Butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-imidazol-5-yl)methanol
2-n-Butyl-4-chloro-5-hydroxymethyl-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]imidazole
MFCD00865831
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
682.0±65.0 °C at 760 mmHg
[ Melting Point ]:
183-184ºC
[ Molecular Formula ]:
C22H23ClN6O
[ Molecular Weight ]:
422.911
[ Flash Point ]:
366.3±34.3 °C
[ Exact Mass ]:
422.162201
[ PSA ]:
92.51000
[ LogP ]:
3.57
[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C
[ Index of Refraction ]:
1.681
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NI6732550
- CHEMICAL NAME :
- 1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)(1,1'- biphenyl)-4-yl)methyl)-
- CAS REGISTRY NUMBER :
- 114798-26-4
- LAST UPDATED :
- 199807
- DATA ITEMS CITED :
- 2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 42 mg/kg/6W-I
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - urine volume decreased
- REFERENCE :
- AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 124,775,1996
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 17500 ug/kg/17W-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Taste) - change in function
- REFERENCE :
- LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 347,471,1996
Safety Information
[ Hazard Codes ]:
Xi: Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S8-S43-S36/37-S22
[ RIDADR ]:
3278
[ WGK Germany ]:
3
[ Packaging Group ]:
III
[ Hazard Class ]:
4.3
[ HS Code ]:
2942000000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%