6'-HYDROXYMETHYL SIMVASTATIN

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Names

[ CAS No. ]:
114883-29-3

[ Name ]:
6'-HYDROXYMETHYL SIMVASTATIN

[Synonym ]:
4-tert-Butyldimethylsilyl-4a'-hydroxy Simvastatin
6'-Hydroxysimvastatin
6(R)-[2-[8(S)-(2,2-Dimethylbutyryloxy)-6(R)-hydroxymethyl-2(S)-methyl-1,2,6,7,8,8a(R)-hexahydronaphthyl-1(S)]ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one
6(R)-<2-<4a(S)-Hydroxy-8(S)-((2,2-dimethylbutyryl)oxy)-2(S),6(R)-dimethyl-1,2,4a,5,6,7,8,8a(S)-octahydronaphth-1(S)-yl>ethyl>-4(R)-((tert-butyldimethylsilyl)oxy)-3,4,5,6-tetrahydro-2H-pyran-2-one
6`-Hydroxymethyl Simvastatin
2,2-Dimethyl-butanoic Acid [1S-[1|A,3|A,4a|A,7|A,8|A(2S*,4S*),8a|A]]-8-[2-[4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]tetrahydro-6-oxo-2H-pyran-2-yl]ethyl]-1,2,3,4,4a,7,8,8a-octahydro-4a-hydroxy-3,7-dimethyl-1-naphthalenyl Ester
6(R)-[2-[8(S)-(2,2-dimethylbutyryloxy)-2(S)-methyl-6(R)-hydroxymethyl-1,2,6,7,8,8a(R)-hexahydronaphthyl-1(S)]ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one
6(R)-[2-[6(R)-hydroxymethyl-8(S)-(2,2-dimethylbutyryloxy)-2(S)-methyl-1,2,6,7,8,8a(R)-hexa-hydronaphthyl-1(S)]ethyl]-4(R)-hydroxy-3,4,5,6 tetra-hydro-2H-pyran-2-one
6(R)-[2-[4a(S)-hydroxy-8(S)-(2,2-dimethylbutyryloxy)-2(S),6(R)-dimethyl-1,2,4a,5,6,7,8,8a(S) octahydronaphthyl-1(S)]ethyl]-4(R)-(t-butyldimethylsilyloxy)-3,4,5,6-tetrahydro-2H-pyran-2-one

Chemical & Physical Properties

[ Molecular Formula ]:
C25H38O6

[ Molecular Weight ]:
434.56600

[ Exact Mass ]:
434.26700

[ PSA ]:
93.06000

[ LogP ]:
3.55800

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4a',6'-Anhydro-4-tert-butyldimethylsilyl Simvastatin
  • Simvastatin
  • 6(R)-[2-[8(S)-((2,2-Dimethylbutyryl)oxy)-2(S),6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydronaphth-1(S)-yl]ethyl]-4(R)-((tert-butyldimethylsilyl)oxy)-3,4,5,6-tetrahydro-2H-pyran-2-one
  • [(1S,3R,4S,4aS,7S,8S,8aS)-8-[2-[(2R,4R)-4-[tert-butyl(dimethyl)silyl]oxy-6-oxooxan-2-yl]ethyl]-4-chloro-4a-hydroxy-3,7-dimethyl-2,3,4,7,8,8a-hexahydro-1H-naphthalen-1-yl] 2,2-dimethylbutanoate

DownStream

Related Compounds

  • 6'-hydroxymethyl simvastatin
  • 6'-HYDROXYMETHYL SIMVASTATIN ACID SODIUM SALT
  • methyl 6'-(hydroxymethyl)-2',3',4,4'-tetramethoxybiphenyl-2-carboxylate
  • 2'-amino-6'-(hydroxymethyl)-2,8'-dioxo-8'H-spiro[indoline-3,4'-pyrano[3,2-b]pyran]-3'-carbonitrile
  • 6-(hydroxymethyl)-6'-(bromomethyl)-2,2'-dipyridine
  • 2,3-O-cyclohexylidene-(L)-Lyxonic acid γ-lactone
  • 5-Amino-2,3-difluoro-N,N,4-trimethylbenzene-1-sulfonamide
  • (3R,4R)-4-[(1-Ethyl-1H-pyrazol-4-yl)oxy]oxolan-3-ol
  • 2-Methyl-7-(trifluoromethyl)-1,2,3,4-tetrahydrophthalazin-1-one
  • 4-(2,2,3,3-Tetramethylcyclopropyl)-1,3-thiazole-2-carbonitrile
  • 4-Amino-5-fluoro-2-methoxy-N,N-dimethylbenzamide
  • 3-(2-Chloroethyl)-1-azabicyclo[2.2.2]octane
  • 7-[(tert-Butoxy)carbonyl]-2-methyl-5H,6H,7H,8H-imidazo[1,2-a]pyrazine-3-carboxylic acid
  • [1-(difluoromethyl)-4,5,6,7-tetrahydro-1H-indol-3-yl]methanamine
  • 2-{1-[(Tert-butoxy)carbonyl]piperidin-4-yl}-4-methyl-1,3-oxazole-5-carboxylic acid
  • 2-Amino-5-(methoxymethyl)-6-methyl-4H,7H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one
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