N-Des-t-boc-10-deacetyl-7,10-O-bis{[(2,2,2-trichloroethyl)oxy]carbonyl} Docetaxel

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Names

[ CAS No. ]:
114915-16-1

[ Name ]:
N-Des-t-boc-10-deacetyl-7,10-O-bis{[(2,2,2-trichloroethyl)oxy]carbonyl} Docetaxel

[Synonym ]:
4-Acetoxy-13-[(3-amino-2-hydroxy-3-phenylpropanoyl)oxy]-7,10-bis({[2-chloro-2-(1λ<sup>3</sup>-dichloran-1-ylidene)ethoxy]carbonyl}oxy)-1-hydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate

Chemical & Physical Properties

[ Molecular Formula ]:
C44H47Cl6NO16

[ Molecular Weight ]:
1058.56000

[ Exact Mass ]:
1055.10000

[ PSA ]:
242.74000

[ LogP ]:
7.30970

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 13-{[(3-N-Boc)-2,2-dimethyl-4S-phenyl-1,3-oxazolidin-5R-yl]formyl}-10-deacetyl-7,10-bis{[(2,2,2-trichloroethyl)oxy]carbonyl} Baccatin III
  • 7,10-di-Troc-Docetaxel
  • Ethyl 3-Azido-2-hydroxy-propionate
  • Benzaldehyde
  • 7,10-Bis-O-(2,2,2-trichloroethoxycarbonyl)-10-deacetylbaccatin III
  • (2R,3S)-3-Phenylisoserine ethyl ester
  • N-(t-Boc)-3-phenyl Isoserine Ethyl Ester
  • (4S,5R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid

DownStream

  • Deacetyltaxol
  • 7,10-di-Troc-Docetaxel

Related Compounds

  • 1-{[(4-Chloro-2-nitrophenyl)sulfonyl]acetyl}pyrrolidine
  • 4-{[(4-Methoxy-2-nitrophenyl)sulfonyl]acetyl}morpholine
  • 2-{[(4-Methoxyphenyl)sulfonyl]acetyl}hydrazinecarbothioamide
  • 4,4-Dimethyl-5,6-dihydro-4h-cyclopenta[d]thiazole-2-carboxylic acid
  • 6,6-Dimethyl-2-oxaspiro[4.4]nonane-1,3-dione
  • [3-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]-6-oxo-5,6-dihydropyridazin-1(4H)-yl]acetic acid
  • [3-[3-(3-fluorophenyl)-1,2,4-oxadiazol-5-yl]-6-oxo-5,6-dihydropyridazin-1(4H)-yl]acetic acid
  • 3-[2-(3-chlorophenyl)-1H-imidazol-5-yl]propanoic acid
  • 1-((Tert-butoxycarbonyl)amino)-2,2-dimethylcyclopentanecarboxylic acid
  • [3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]-6-oxo-5,6-dihydropyridazin-1(4H)-yl]acetic acid
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