N-Des-t-boc-10-deacetyl-7,10-O-bis{[(2,2,2-trichloroethyl)oxy]carbonyl} Docetaxel

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Names

[ CAS No. ]:
114915-16-1

[ Name ]:
N-Des-t-boc-10-deacetyl-7,10-O-bis{[(2,2,2-trichloroethyl)oxy]carbonyl} Docetaxel

[Synonym ]:
4-Acetoxy-13-[(3-amino-2-hydroxy-3-phenylpropanoyl)oxy]-7,10-bis({[2-chloro-2-(1λ<sup>3</sup>-dichloran-1-ylidene)ethoxy]carbonyl}oxy)-1-hydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate

Chemical & Physical Properties

[ Molecular Formula ]:
C44H47Cl6NO16

[ Molecular Weight ]:
1058.56000

[ Exact Mass ]:
1055.10000

[ PSA ]:
242.74000

[ LogP ]:
7.30970

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 13-{[(3-N-Boc)-2,2-dimethyl-4S-phenyl-1,3-oxazolidin-5R-yl]formyl}-10-deacetyl-7,10-bis{[(2,2,2-trichloroethyl)oxy]carbonyl} Baccatin III
  • 7,10-di-Troc-Docetaxel
  • Ethyl 3-Azido-2-hydroxy-propionate
  • Benzaldehyde
  • 7,10-Bis-O-(2,2,2-trichloroethoxycarbonyl)-10-deacetylbaccatin III
  • (2R,3S)-3-Phenylisoserine ethyl ester
  • N-(t-Boc)-3-phenyl Isoserine Ethyl Ester
  • (4S,5R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid

DownStream

  • Deacetyltaxol
  • 7,10-di-Troc-Docetaxel

Related Compounds

  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 7-Chloro-4-cyclopentylthiazolo[5,4-b]pyridin-5(4H)-one
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide