N-Des-t-boc-10-deacetyl-7,10-O-bis{[(2,2,2-trichloroethyl)oxy]carbonyl} Docetaxel

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Names

[ CAS No. ]:
114915-16-1

[ Name ]:
N-Des-t-boc-10-deacetyl-7,10-O-bis{[(2,2,2-trichloroethyl)oxy]carbonyl} Docetaxel

[Synonym ]:
4-Acetoxy-13-[(3-amino-2-hydroxy-3-phenylpropanoyl)oxy]-7,10-bis({[2-chloro-2-(1λ<sup>3</sup>-dichloran-1-ylidene)ethoxy]carbonyl}oxy)-1-hydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate

Chemical & Physical Properties

[ Molecular Formula ]:
C44H47Cl6NO16

[ Molecular Weight ]:
1058.56000

[ Exact Mass ]:
1055.10000

[ PSA ]:
242.74000

[ LogP ]:
7.30970

Synthetic Route

Precursor & DownStream

Precursor

  • 13-{[(3-N-Boc)-2,2-dimethyl-4S-phenyl-1,3-oxazolidin-5R-yl]formyl}-10-deacetyl-7,10-bis{[(2,2,2-trichloroethyl)oxy]carbonyl} Baccatin III
  • 7,10-di-Troc-Docetaxel
  • Ethyl 3-Azido-2-hydroxy-propionate
  • Benzaldehyde
  • 7,10-Bis-O-(2,2,2-trichloroethoxycarbonyl)-10-deacetylbaccatin III
  • (2R,3S)-3-Phenylisoserine ethyl ester
  • N-(t-Boc)-3-phenyl Isoserine Ethyl Ester
  • (4S,5R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid

DownStream

  • Deacetyltaxol
  • 7,10-di-Troc-Docetaxel

Related Compounds

  • Propanoic acid, 2-methyl-2-(3-methylphenoxy)-, phenylmethyl ester
  • 1-(4-Chlorophenyl)-2-(5-chloropyridin-3-yl)ethanone
  • Ethyl 4-methoxy-2-methyl-2H-indazole-6-carboxylate
  • 7-bromo-3-propylquinazolin-4(3H)-one
  • 3-hydroxy-1H-pyrrole-2-carboxylic acid
  • 3-Quinolinecarboxamide,n-ethyl-1,2-dihydro-4-hydroxy-1,6-dimethyl-2-oxo-n-phenyl-
  • 2-(3-Oxo-6-hydroxy-3H-xanthene-9-yl)benzoate
  • L-Ascorbic acid 2-glucoside
  • (4S,4aR,5S,5aR,6R,12aR)-9-tert-butyl-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide
  • 4-(5-Bromo-6-chloro-pyrazin-2-yloxy)-piperidine-1-carboxylic acid tert-butyl ester
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