Sinomenine
Suppliers
Names
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
513.6±50.0 °C at 760 mmHg
[ Melting Point ]:
180ºC
[ Molecular Formula ]:
C19H23NO4
[ Molecular Weight ]:
329.390
[ Flash Point ]:
264.4±30.1 °C
[ Exact Mass ]:
329.162720
[ PSA ]:
59.00000
[ LogP ]:
1.25
[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C
[ Index of Refraction ]:
1.625
[ Storage condition ]:
2~8°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QD2170000
- CHEMICAL NAME :
- 9-alpha,13-alpha,14-alpha-Morphinan-6-one, 7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-
- CAS REGISTRY NUMBER :
- 115-53-7
- BEILSTEIN REFERENCE NO. :
- 0095280
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C19-H23-N-O4
- MOLECULAR WEIGHT :
- 329.43
- WISWESSER LINE NOTATION :
- T6 G666/FQ 2AF Q DV FX ON BUT&TTJ CO1 HQ IO1 O1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 580 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- YHHPAL Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1953- Suspended 1966-78. Volume(issue)/page/year: 10,673,1963
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 285 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- YHHPAL Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1953- Suspended 1966-78. Volume(issue)/page/year: 8,177,1960
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H315-H319-H335
[ Precautionary Statements ]:
P301 + P312 + P330-P305 + P351 + P338
[ Hazard Codes ]:
T: Toxic;
[ Risk Phrases ]:
R45
[ Safety Phrases ]:
53-22-26-36/37/39-45
[ RIDADR ]:
UN 1544
[ WGK Germany ]:
3
[ RTECS ]:
QD2170000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Zhong Xi Yi Jie He Xue Bao 7(8) , 775-8, (2009)
Zhongguo Zhong Yao Za Zhi 30(20) , 1573-6, (2005)
To further understand sinomenine, this paper has introduced the abstract technology, assaying, pharmaceutical chemistry, pharmacological action, pharmacotoxicology, pharmacokinetics and clinical appli...
Int. Immunopharmacol. 11(3) , 373-6, (2011)
Sinomenine (SN), a pure compound extracted from the Sinomenium acutum plant, has been found to inhibit T- and B-lymphocyte activation, proliferation and function and to interfere with the differentiat...