Dofetilide

Suppliers

Names

[ CAS No. ]:
115256-11-6

[ Name ]:
Dofetilide

[Synonym ]:
N-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]methanesulfon Amide
Dofetilidum
Xelide
N-[4-[2-[2-[4-(methanesulfonamido)phenoxy]ethyl-methylamino]ethyl]phenyl]methanesulfonamide
MFCD00869707
Dofetilide
1-MSPMPE
b-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide
N-(4-{2-[Methyl(2-{4-[(methylsulfonyl)amino]phenoxy}ethyl)amino]ethyl}phenyl)methanesulfonamide
Dofetilida
Methanesulfonamide, N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-
Tikosyn

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
614.1±65.0 °C at 760 mmHg

[ Melting Point ]:
147-1490C

[ Molecular Formula ]:
C19H27N3O5S2

[ Molecular Weight ]:
441.565

[ Flash Point ]:
325.2±34.3 °C

[ Exact Mass ]:
441.139221

[ PSA ]:
121.57000

[ LogP ]:
1.56

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.614

[ Storage condition ]:
Store at RT

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
PB0478000
CHEMICAL NAME :
Methanesulfonamide, N-(4-(2-(methyl(2-(4-((methylsulfonyl)amino)phenoxy)e thyl)amino)ethyl) phenyl)-
CAS REGISTRY NUMBER :
115256-11-6
LAST UPDATED :
199806
DATA ITEMS CITED :
3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
22050 ug/kg
SEX/DURATION :
female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 53,168,1996
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
11025 ug/kg
SEX/DURATION :
female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 53,168,1996
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
44100 ug/kg
SEX/DURATION :
female 14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 53,168,1996

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H360

[ Precautionary Statements ]:
P201-P308 + P313

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
26-37/39

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Methanesulfonamide
  • Methanesulfonyl chloride
  • 1-(4-methanesulphonamidophenoxy)-2-[N-methyl-N-(4-aminophenethyl)amino]ethane
  • β-Chloro-4-nitrophenethole
  • Benzeneethanamine, N-Methyl-4-nitro-
  • N-methyl-2-(4-nitrophenoxy)-N-[2-(4-nitrophenyl)ethyl]ethanamine
  • N-Methyl-N-(2-(4-aminophenoxy)ethyl)-2-(4-aminophenyl)ethanamine
  • Mesyl anhydride
  • 4-nitrophenylethylamine hydrobromide

DownStream

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Related Compounds

  • Dofetilide D4
  • Dofetilide N-oxide
  • 7-Methoxy-5-methyl-3-phenyl-2H-1-benzopyran-2-one
  • 6-[Methyl(propan-2-yl)amino]hexanal
  • 1,1'-(Dithiodi-2,1-ethanediyl)bis[4-piperidineethanol]
  • 2,4-Dibromo-3,5-dimethylbenzonitrile
  • 5-(Chloromethyl)-6-methylenebicyclo[2.2.1]hept-2-ene
  • 3-(Piperidin-3-yl)benzonitrile hydrochloride
  • 4-(2-Azidoethyl)-1-ethoxy-2-methoxybenzene
  • tert-Butyl 2-(hydroxymethyl)-5-oxopiperazine-1-carboxylate
  • 6-(Butan-2-yl)pyridine-3-carboxylic acid
  • 1-[(Tert-butoxy)carbonyl]-2-cyclopropylpyrrolidine-3-carboxylic acid
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