Sodium risedronate

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Names

[ CAS No. ]:
115436-72-1

[ Name ]:
Sodium risedronate

[Synonym ]:
T6NJ C1XQPQQO&PQQO &&Mono Na salt
Actonel
Natriumhydrogen-(1-hydroxy-1-phosphono-2-pyridin-3-ylethyl)phosphonat
Risedronic acid monosodium salt
sodium hydrogen (1-hydroxy-1-phosphono-2-pyridin-3-ylethyl)phosphonate
Benet
hydrogène (1-hydroxy-1-phosphono-2-pyridin-3-yléthyl)phosphonate de sodium
Phosphonic acid, [1-hydroxy-2-(3-pyridinyl)ethylidene]bis-, sodium salt (1:1)
MFCD01706268
phosphonic acid, [1-hydroxy-2-(3-pyridinyl)ethylidene]bis-, monosodium salt
Sodium risedronate
sodium hydrogen [1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl]phosphonate
P,P'-[1-Hydroxy-2-(3-pyridonyl)ethylidene]bis-phosphonic acid sodium salt
Sodium hydrogen [1-hydroxy-1-phosphono-2-(3-pyridinyl)ethyl]phosphonate
Risedronic acid sodium salt
sodium hydrogen-1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethylphosphonate
[1-Hydroxy-2-(3-pyridinyl)ethylidene]bis(phosphonic acid), sodium salt (1:1)
Optinate
Risedronate sodium

Chemical & Physical Properties

[ Boiling Point ]:
692.3ºC at 760 mmHg

[ Melting Point ]:
252-262°C

[ Molecular Formula ]:
C7H10NNaO7P2

[ Molecular Weight ]:
305.094

[ Flash Point ]:
372.5ºC

[ Exact Mass ]:
304.983032

[ PSA ]:
170.63000

[ LogP ]:
0.06380

[ Vapour Pressure ]:
4.03E-20mmHg at 25°C

[ Storage condition ]:
Store at RT

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SZ8567500
CHEMICAL NAME :
Phosphonic acid, (1-hydroxy-2-(3-pyridinyl)ethylidene)bis-, monosodium salt
CAS REGISTRY NUMBER :
115436-72-1
LAST UPDATED :
199504
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C7-H10-N-O7-P2.Na
MOLECULAR WEIGHT :
305.11

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
1800 ug/kg/3D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - iritis
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 341,436,1993

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332

[ Precautionary Statements ]:
P280

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
SZ8567500

Articles

Ionic complex of risedronate with positively charged deoxycholic acid derivative: evaluation of physicochemical properties and enhancement of intestinal absorption in rats.

Arch. Pharm. Res. 37(12) , 1560-9, (2014)

Risedronate is widely used clinically to treat osteoporosis, Paget's disease, hypercalcemia, bone metastasis, and multiple myeloma. However, its oral efficacy is restricted due to its low bioavailabil...

Effects of various squalene epoxides on coenzyme Q and cholesterol synthesis.

Biochim. Biophys. Acta 1841(7) , 977-86, (2014)

2,3-Oxidosqualene is an intermediate in cholesterol biosynthesis and 2,3:22,23-dioxidosqualene act as the substrate for an alternative pathway that produces 24(S),25-epoxycholesterol which effects cho...

Risedronate increases osteoblastic differentiation and function through connexin43.

Biochem. Biophys. Res. Commun. 432(1) , 152-6, (2013)

Bisphosphonates are potent antiresorptive drugs which have antifracture efficacy by reducing bone turnover rate and increasing bone mineral density. In addition to inhibiting osteoclast function, bisp...


More Articles

Related Compounds

  • sodium,(1-hydroxy-1-phosphono-2-pyridin-2-ylethyl)phosphonic acid
  • sodium 2-ethylhexanolate
  • sodium,(4Z)-4-hydroxyimino-3-oxo-1,2-dihydronaphthalene-1-sulfonate
  • sodium,trisilylsilanide
  • sodium,(Z)-4-[(2-amino-3-methylbutanoyl)amino]-3-chloro-5-hydroxy-5-oxopent-2-enoate
  • sodium lauroamphoacetate
  • 1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylcyclobutane-1-carboxylic acid
  • 2-{[(Benzyloxy)carbonyl]amino}-2-[2-(trifluoromethoxy)phenyl]acetic acid
  • tert-Butyl isoindoline-5-carboxylate
  • Benzyl 3-aminobicyclo[1.1.1]pentane-1-carboxylate
  • tert-butyl (2S)-2-amino-3-(pyrimidin-5-yl)propanoate
  • Tert-butyl 1-(2-aminoethyl)cyclopropane-1-carboxylate
  • 6-Bromo-N-(1,1-dimethylethyl)-5-fluoro-3-methyl-2-pyridinamine
  • 4-bromo-N-(6-fluoro-1,3-dimethyl-2,2-dioxido-1,3-dihydrobenzo[c][1,2,5]thiadiazol-5-yl)benzamide
  • 6-Benzofuranmethanamine, 5,7-difluoro-2,3-dihydro-I+/-,I+/--dimethyl-
  • 7-Bromo-6-chloro-1-benzothiophene
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