ipazilide fumarate

Suppliers

Names

[ Name ]:
ipazilide fumarate

[Synonym ]:
IPAZILIDE FUMARATE
N-(3-(Diethylamino)propyl)-4,5-diphenyl-1H-pyrazole-1-acetamide (E)-2-butenedioate (1:1)
Ipazilide fumarate (USAN)
1H-Pyrazole-1-acetamide,N-(3-(diethylamino)propyl)-4,5-diphenyl-,(E)-2-butenedioate (1:1)
N-[3-(diethylamino)propyl]-2-(4,5-diphenyl-1H-pyrazol-1-yl)acetamide (2E)-but-2-enedioate

Chemical & Physical Properties

[ Boiling Point ]:
569.7ºC at 760mmHg

[ Molecular Formula ]:
C₂₈H₃₄N₄O₅

[ Molecular Weight ]:
506.59300

[ Flash Point ]:
298.4ºC

[ Exact Mass ]:
506.25300

[ PSA ]:
128.25000

[ LogP ]:
4.61730

[ Vapour Pressure ]:
5.4E-13mmHg at 25°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ4903600

CAS REGISTRY NUMBER :: 115436-74-3

LAST UPDATED :: 199403

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C24-H30-N4-O.C4-H4-O4

MOLECULAR WEIGHT :: 506.66

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Cardiac - pulse rate increase, without fall in BP

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 18,581,1992 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 29200 mg/kg/1Y-I

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in thyroid weight Blood - changes in leukocyte (WBC) count

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 20,147,1993

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9280 mg/kg/29D-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - proteinuria Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 18,581,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 870 mg/kg/29D-I

TOXIC EFFECTS :: Cardiac - pulse rate increase, without fall in BP Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 18,581,1992

Related Compounds

Ipazilide
Hexyl fumarate
Monomethyl fumarate-d5
DIOCTYL FUMARATE
diethyl fumarate
DIOCTYL FUMARATE
N-cyclopropyl-2-{4H,5H,6H,7H-furo[3,2-c]pyridin-4-yl}acetamide
5-{4H,5H,6H,7H-furo[2,3-c]pyridin-7-yl}-2-methyl-1,3-thiazole
4-(4-methanesulfonyl-1H-pyrazol-1-yl)-2-methylbenzoic acid
1-[(3-bromo-1-methyl-1H-pyrazol-4-yl)methyl]-5-methyl-1H-pyrazol-4-amine
3-Amino-1-[(thiolan-2-yl)methyl]-1,2-dihydropyridin-2-one
2-[2-(tert-butylsulfanyl)ethyl]-2H-1,2,3-triazol-4-amine
2-[(4-amino-1H-1,2,3-triazol-1-yl)methyl]-6-methyl-3,4-dihydropyrimidin-4-one
2-[4-(Morpholine-4-carbonyl)piperidin-1-yl]-4,5,6,7-tetrahydro-1,3-benzothiazole
6-Chloro-2-(oxolan-3-yl)quinolin-3-ol
1-(3-{2-Azabicyclo[3.2.0]heptan-1-yl}piperidin-1-yl)-3-methylbutan-1-one

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