ipazilide fumarate

Suppliers

Names

[ Name ]:
ipazilide fumarate

[Synonym ]:
IPAZILIDE FUMARATE
N-(3-(Diethylamino)propyl)-4,5-diphenyl-1H-pyrazole-1-acetamide (E)-2-butenedioate (1:1)
Ipazilide fumarate (USAN)
1H-Pyrazole-1-acetamide,N-(3-(diethylamino)propyl)-4,5-diphenyl-,(E)-2-butenedioate (1:1)
N-[3-(diethylamino)propyl]-2-(4,5-diphenyl-1H-pyrazol-1-yl)acetamide (2E)-but-2-enedioate

Chemical & Physical Properties

[ Boiling Point ]:
569.7ºC at 760mmHg

[ Molecular Formula ]:
C₂₈H₃₄N₄O₅

[ Molecular Weight ]:
506.59300

[ Flash Point ]:
298.4ºC

[ Exact Mass ]:
506.25300

[ PSA ]:
128.25000

[ LogP ]:
4.61730

[ Vapour Pressure ]:
5.4E-13mmHg at 25°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ4903600

CAS REGISTRY NUMBER :: 115436-74-3

LAST UPDATED :: 199403

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C24-H30-N4-O.C4-H4-O4

MOLECULAR WEIGHT :: 506.66

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Cardiac - pulse rate increase, without fall in BP

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 18,581,1992 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 29200 mg/kg/1Y-I

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in thyroid weight Blood - changes in leukocyte (WBC) count

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 20,147,1993

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9280 mg/kg/29D-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - proteinuria Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 18,581,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 870 mg/kg/29D-I

TOXIC EFFECTS :: Cardiac - pulse rate increase, without fall in BP Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 18,581,1992

Related Compounds

Ipazilide
Hexyl fumarate
Monomethyl fumarate-d5
DIOCTYL FUMARATE
diethyl fumarate
DIOCTYL FUMARATE
N-(1H-benzimidazol-6-yl)-1-(furan-2-ylmethyl)-5-oxopyrrolidine-3-carboxamide
N-[2-(cyclohex-1-en-1-yl)ethyl]-2-[4-(1H-pyrrol-1-yl)tetrahydro-2H-pyran-4-yl]acetamide
5-(4-fluorophenyl)-4-iodo-1H-pyrazole-3-carboxylic acid
ethyl 4-[(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoyl]piperazine-1-carboxylate
N-benzyl-4-(5,11-dioxo-6a,11-dihydroisoindolo[2,1-a]quinazolin-6(5H)-yl)butanamide
Tert-butyl 5-bromo-1-methylisoindoline-2-carboxylate
methyl N-[6-(9,10-dimethoxy-5,11-dioxo-6a,11-dihydroisoindolo[2,1-a]quinazolin-6(5H)-yl)hexanoyl]glycinate
9,10-Dimethoxy-6-[6-oxo-6-(pyrrolidin-1-yl)hexyl]-6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-dione
N-(5,6-dihydro-4H-cyclopenta[d][1,3]thiazol-2-yl)-3-(5,11-dioxo-6a,11-dihydroisoindolo[2,1-a]quinazolin-6(5H)-yl)propanamide
(6-chloro-1-methyl-1H-indol-2-yl)(1,3,4,9-tetrahydro-2H-beta-carbolin-2-yl)methanone

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