Tolazamide
Suppliers
Names
[ CAS No. ]:
1156-19-0
[ Name ]:
Tolazamide
[Synonym ]:
1-(azepan-1-yl)-3-(4-methylphenyl)sulfonylurea
1-(Hexahydro-1H-azepin-1-yl)-3-(p-toluenesulfonyl)urea
Tolazamide
EINECS 214-588-3
MFCD00083504
Chemical & Physical Properties
[ Density]:
1.29g/cm3
[ Boiling Point ]:
289 °C772 mm Hg(lit.)
[ Melting Point ]:
171-173 °C(lit.)
[ Molecular Formula ]:
C14H21N3O3S
[ Molecular Weight ]:
311.40000
[ Flash Point ]:
100 °C
[ Exact Mass ]:
311.13000
[ PSA ]:
86.89000
[ LogP ]:
3.57440
[ Index of Refraction ]:
1.596
[ Storage condition ]:
Refrigerator
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YT4400000
- CHEMICAL NAME :
- Urea, 1-(hexahydro-1H-azepin-1-yl)-3-(p-tolylsulfonyl)-
- CAS REGISTRY NUMBER :
- 1156-19-0
- BEILSTEIN REFERENCE NO. :
- 1323565
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C14-H21-N3-O3-S
- MOLECULAR WEIGHT :
- 311.44
- WISWESSER LINE NOTATION :
- T7NTJ AMVMSWR D1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 256 mg/kg/3W-I
- TOXIC EFFECTS :
- Liver - jaundice, other or unclassified Liver - liver function tests impaired
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- DNA damage
- TEST SYSTEM :
- Rodent - rat Liver
- DOSE/DURATION :
- 4 mmol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 368,59,1996
Safety Information
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
R22
[ Safety Phrases ]:
S36
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
YT4400000
[ HS Code ]:
2935009090
Customs
[ HS Code ]: 2935009090
[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%