Dolasetron (Mesylate)

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Names

[ Name ]:
Dolasetron (Mesylate)

[Synonym ]:
(1r,3R,5r,7S)-10-Oxo-8-azatricyclo[5.3.1.0]undec-5-yl 1H-indole-3-carboxylate methanesulfonate hydrate (1:1:1)
MFCD01718979
Dolasetron mesylate
(3R,5r,7S)-10-Oxo-8-azatricyclo[5.3.1.0]undec-5-yl 1H-indole-3-carboxylate methanesulfonate hydrate (1:1:1)
1H-Indole-3-carboxylic acid, (6R,9aS)-octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, methanesulfonate, hydrate (1:1:1)
EINECS 214-599-3
Dolasetron (Mesylate)

Chemical & Physical Properties

[ Boiling Point ]:
535.1ºC at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₄N₂O₆S

[ Molecular Weight ]:
420.48

[ Flash Point ]:
277.4ºC

[ PSA ]:
134.38000

[ LogP ]:
2.97740

[ Vapour Pressure ]:
1.65E-22mmHg at 25°C

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NL6015300

CHEMICAL NAME :: 1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, (2-alpha,6-alpha,8-alpha,9a-beta)-, monomethanesulfonate, monohydrate

CAS REGISTRY NUMBER :: 115956-13-3

LAST UPDATED :: 199801

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C19-H20-N2-O3.C-H4-O3-S.H2-O

MOLECULAR WEIGHT :: 438.54

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 2400 ug/kg

TOXIC EFFECTS :: Behavioral - headache Gastrointestinal - decreased motility or constipation Gastrointestinal - other changes

REFERENCE :: BDDID8 Biopharmaceutics & Drug Disposition. (John Wiley & Sons, Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1979- Volume(issue)/page/year: 18,361,1997

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 2400 ug/kg/10M-C

TOXIC EFFECTS :: Behavioral - hallucinations, distorted perceptions Behavioral - headache

REFERENCE :: BDDID8 Biopharmaceutics & Drug Disposition. (John Wiley & Sons, Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1979- Volume(issue)/page/year: 18,361,1997

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 545 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 18,506,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 165 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 18,506,1993

Safety Information

[ Risk Phrases ]:
R20/21/22

Related Compounds

Dolasetron (Mesylate hydrate)
Dolasetron
BPR1R024 mesylate
Larotinib mesylate hydrate
Pirlindole mesylate
TVP1022 (mesylate)
Ethyl (S)-2-amino-2-(bicyclo[1.1.1]pentan-1-yl)acetate hydrochloride
5-Chloro-2,7-bis(difluoromethyl)-[1,2,4]triazolo[1,5-a]pyridine
5-Chloro-7-(cyclopropylmethyl)-2-(methoxymethyl)-[1,2,4]triazolo[1,5-a]pyridine
5-Chloro-7-cyclopentyl-[1,2,4]triazolo[1,5-a]pyridine
5-Chloro-7-cyclobutyl-[1,2,4]triazolo[1,5-a]pyridine
5-Chloro-2-methyl-7-(2-methylpropyl)-[1,2,4]triazolo[1,5-a]pyridine
5-Chloro-2-(methoxymethyl)-7-(2-methylpropyl)-[1,2,4]triazolo[1,5-a]pyridine
5-Chloro-2,6-diethyl-7-(propan-2-yl)-[1,2,4]triazolo[1,5-a]pyridine
1-(4-methoxybutyl)-5-methyl-1H-pyrazol-3-amine
5-methyl-1-[2-(propan-2-ylsulfanyl)ethyl]-1H-pyrazol-3-amine

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