Dolasetron (Mesylate)

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Names

[ CAS No. ]:
115956-13-3

[ Name ]:
Dolasetron (Mesylate)

[Synonym ]:
(1r,3R,5r,7S)-10-Oxo-8-azatricyclo[5.3.1.0]undec-5-yl 1H-indole-3-carboxylate methanesulfonate hydrate (1:1:1)
MFCD01718979
Dolasetron mesylate
(3R,5r,7S)-10-Oxo-8-azatricyclo[5.3.1.0]undec-5-yl 1H-indole-3-carboxylate methanesulfonate hydrate (1:1:1)
1H-Indole-3-carboxylic acid, (6R,9aS)-octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, methanesulfonate, hydrate (1:1:1)
EINECS 214-599-3
Dolasetron (Mesylate)

Chemical & Physical Properties

[ Boiling Point ]:
535.1ºC at 760 mmHg

[ Molecular Formula ]:
C20H24N2O6S

[ Molecular Weight ]:
420.48

[ Flash Point ]:
277.4ºC

[ PSA ]:
134.38000

[ LogP ]:
2.97740

[ Vapour Pressure ]:
1.65E-22mmHg at 25°C

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NL6015300
CHEMICAL NAME :
1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, (2-alpha,6-alpha,8-alpha,9a-beta)-, monomethanesulfonate, monohydrate
CAS REGISTRY NUMBER :
115956-13-3
LAST UPDATED :
199801
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C19-H20-N2-O3.C-H4-O3-S.H2-O
MOLECULAR WEIGHT :
438.54

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
2400 ug/kg
TOXIC EFFECTS :
Behavioral - headache Gastrointestinal - decreased motility or constipation Gastrointestinal - other changes
REFERENCE :
BDDID8 Biopharmaceutics & Drug Disposition. (John Wiley & Sons, Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1979- Volume(issue)/page/year: 18,361,1997
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
2400 ug/kg/10M-C
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions Behavioral - headache
REFERENCE :
BDDID8 Biopharmaceutics & Drug Disposition. (John Wiley & Sons, Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1979- Volume(issue)/page/year: 18,361,1997
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
545 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 18,506,1993
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
165 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 18,506,1993

Safety Information

[ Risk Phrases ]:
R20/21/22

Related Compounds

  • Dolasetron (Mesylate hydrate)
  • Dolasetron
  • BPR1R024 mesylate
  • Larotinib mesylate hydrate
  • Pirlindole mesylate
  • TVP1022 (mesylate)
  • Ethyl 3-amino-4-methoxyhexanoate
  • O-[(3,4-dibromophenyl)methyl]hydroxylamine
  • 4-(Pyrazin-2-yl)pyrrolidin-3-ol
  • 3-Amino-1-(propoxymethyl)-1,2-dihydropyridin-2-one
  • CID 165899115
  • 1-[1-(2-Fluoro-5-nitrophenyl)cyclopropyl]cyclopropan-1-amine
  • Methyl 1-{bicyclo[3.2.0]heptan-2-yl}piperidine-4-carboxylate
  • 8-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,5,6-triazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7-tetraene
  • 4-Methyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,5,6-triazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7-tetraene
  • 2-bromo-1-{1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl}ethan-1-ol
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