Dolasetron (Mesylate)
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Names
[ CAS No. ]:
115956-13-3
[ Name ]:
Dolasetron (Mesylate)
[Synonym ]:
(1r,3R,5r,7S)-10-Oxo-8-azatricyclo[5.3.1.0]undec-5-yl 1H-indole-3-carboxylate methanesulfonate hydrate (1:1:1)
MFCD01718979
Dolasetron mesylate
(3R,5r,7S)-10-Oxo-8-azatricyclo[5.3.1.0]undec-5-yl 1H-indole-3-carboxylate methanesulfonate hydrate (1:1:1)
1H-Indole-3-carboxylic acid, (6R,9aS)-octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, methanesulfonate, hydrate (1:1:1)
EINECS 214-599-3
Dolasetron (Mesylate)
Chemical & Physical Properties
[ Boiling Point ]:
535.1ºC at 760 mmHg
[ Molecular Formula ]:
C20H24N2O6S
[ Molecular Weight ]:
420.48
[ Flash Point ]:
277.4ºC
[ PSA ]:
134.38000
[ LogP ]:
2.97740
[ Vapour Pressure ]:
1.65E-22mmHg at 25°C
[ Storage condition ]:
2-8°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NL6015300
- CHEMICAL NAME :
- 1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, (2-alpha,6-alpha,8-alpha,9a-beta)-, monomethanesulfonate, monohydrate
- CAS REGISTRY NUMBER :
- 115956-13-3
- LAST UPDATED :
- 199801
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C19-H20-N2-O3.C-H4-O3-S.H2-O
- MOLECULAR WEIGHT :
- 438.54
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 2400 ug/kg
- TOXIC EFFECTS :
- Behavioral - headache Gastrointestinal - decreased motility or constipation Gastrointestinal - other changes
- REFERENCE :
- BDDID8 Biopharmaceutics & Drug Disposition. (John Wiley & Sons, Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1979- Volume(issue)/page/year: 18,361,1997
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 2400 ug/kg/10M-C
- TOXIC EFFECTS :
- Behavioral - hallucinations, distorted perceptions Behavioral - headache
- REFERENCE :
- BDDID8 Biopharmaceutics & Drug Disposition. (John Wiley & Sons, Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1979- Volume(issue)/page/year: 18,361,1997
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 545 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 18,506,1993
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 165 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 18,506,1993
Safety Information
[ Risk Phrases ]:
R20/21/22