Di-tert-butyl(2',4',6'-triisopropyl-3,6-dimethoxybiphenyl-2-yl)phosphine

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Names

[ CAS No. ]:
1160861-53-9

[ Name ]:
Di-tert-butyl(2',4',6'-triisopropyl-3,6-dimethoxybiphenyl-2-yl)phosphine

[Synonym ]:
T-BUTYLBRETTPHOS
2-(Di-tert-butylphosphino)-2′,4′,6′- triisopropyl-3,6-dimethoxy-1,1′-biphenyl
tert-Butyl BrettPhos
Bis(2-methyl-2-propanyl)(2',4',6'-triisopropyl-3,6-dimethoxy-2-biphenylyl)phosphine
t-BuBrett Phos
Phosphine, [3,6-dimethoxy-2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]bis(1,1-dimethylethyl)-
tBuBrettPhos
t-BuBrett-Phos
Di-tert-butyl(2',4',6'-triisopropyl-3,6-dimethoxybiphenyl-2-yl)phosphine
t-BuBrettPhos

Chemical & Physical Properties

[ Boiling Point ]:
534.9±50.0 °C at 760 mmHg

[ Melting Point ]:
171 °C

[ Molecular Formula ]:
C31H49O2P

[ Molecular Weight ]:
484.693

[ Flash Point ]:
347.6±30.4 °C

[ Exact Mass ]:
484.347015

[ PSA ]:
32.05000

[ LogP ]:
10.28

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

MSDS

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Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

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Precursor & DownStream

Precursor

  • Di-tert-butylchlorophosphane
  • 2-Bromo-1,3,5-triisopropylbenzene
  • 2-Fluoro-1,4-dimethoxybenzene
  • 2-Iodo-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl
  • magnesium,1,3,5-tri(propan-2-yl)benzene-6-ide,bromide

DownStream

Articles

Palladium-catalyzed Suzuki-Miyaura cross-coupling reactions employing dialkylbiaryl phosphine ligands.

Acc. Chem. Res. 41 , 1461, (2008)

The cores of many types of polymers, ligands, natural products, and pharmaceuticals contain biaryl or substituted aromatic structures, and efficient methods of synthesizing these structures are crucia...

Biaryl phosphane ligands in palladium-catalyzed amination.

Angew. Chem. Int. Ed. Engl. 47 , 6338, (2008)

Palladium-catalyzed amination reactions of aryl halides have undergone rapid development in the last 12 years, largely driven by the implementation of new classes of ligands. Biaryl phosphanes have pr...

Dialkylbiaryl Phosphines in Pd-Catalyzed Amination: A User's Guide.

Chem. Sci. 2 , 27, (2011)

Dialkylbiaryl phosphines are a valuable class of ligand for Pd-catalyzed amination reactions and have been applied in a range of contexts. This review attempts to aid the reader in the selection of th...


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