5-Bromo-2-iodotoluene

Names

[ Name ]:
5-Bromo-2-iodotoluene

[Synonym ]:
4-Bromo-1-iodo-2-methylbenzene
5-Bromo-2-iodotoluene
Benzene, 4-bromo-1-iodo-2-methyl-
IR DE B1
MFCD00060664

Chemical & Physical Properties

[ Density]:
2.1±0.1 g/cm3

[ Boiling Point ]:
264.2±20.0 °C at 760 mmHg

[ Molecular Formula ]:
C₇H₆BrI

[ Molecular Weight ]:
296.931

[ Flash Point ]:
113.6±21.8 °C

[ Exact Mass ]:
295.869751

[ LogP ]:
4.41

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.637

[ Storage condition ]:
Room temperature.

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
2810

[ WGK Germany ]:
3

[ HS Code ]:
2903999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1-Bromo-4-iodobenzene
3-(4-Bromophenyl)-2-propyn-1-ol
4-Iodotoluene
O-ACETOTOLUIDIDE
4-Bromo-2-methylaniline

DownStream

4-bromo-2-(bromomethyl)-1-iodobenzene
4-bromo-2-methyl-1-phenylbenzene
5-(3-methyl-4-phenylphenyl)pentanoic acid
5-Bromo-2-iodobenzaldehyde
(2R)-5-(2-Methyl-4-biphenylyl)-2-{2-[(2-methyl-2-propanyl)oxy]-2- oxoethyl}pentanoic acid
UK 370106
2-Methyl-2-propanyl (3R)-3-{[(2S)-1-{[(1S)-2-methoxy-1-phenylethy l]amino}-3,3-dimethyl-1-oxo-2-butanyl]carbamoyl}-6-(2-methyl-4-bi phenylyl)hexanoate
3-(2-Methylphenyl)pyridine
3-(4-bromo-2-methylphenyl)pyridine
4-bromo-1-[2-(4-ethoxyphenyl)ethynyl]-2-methylbenzene

Customs

[ HS Code ]: 2903999090

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Structure-Based Design of Macrocyclic Coagulation Factor VIIa Inhibitors.

J. Med. Chem. 58 , 6225-36, (2015)

On the basis of a crystal structure of a phenylpyrrolidine lead and subsequent molecular modeling results, we designed and synthesized a novel series of macrocyclic FVIIa inhibitors. The optimal 16-me...

A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers.

J. Med. Chem. 46 , 3514-3525, (2003)

The pathology of chronic dermal ulcers is characterized by excessive proteolytic activity which degrades extracellular matrix (required for cell migration) and growth factors and their receptors. The ...

Synthesis of new phenylpyridyl scaffolds using the Garlanding approach. Voisin-Chiret AS, et al.

Tetrahedron 66(40) , 8000-8005, (2010)

5-Bromo-2-fluoro-4-iodotoluene
5-Bromo-3-chloro-2-iodotoluene
5-Bromo-4-fluoro-2-iodotoluene
5-Bromo-2-(3-methyl-oxetan-3-ylmethoxy)-pyridine
5-bromo-2,4,7-trinitro-fluoren-9-one; fluoranthene
5-bromo-2-methylbenzenesulfonamide
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
3-(6-Chloropyrazin-2-yl)-4,4-difluorobutanoic acid
tert-Butyl-DL-alanine
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide