N-(2-Aminoethyl)isoquinoline-5-sulfonamide hydrochloride

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Names

[ CAS No. ]:
116970-50-4

[ Name ]:
N-(2-Aminoethyl)isoquinoline-5-sulfonamide hydrochloride

[Synonym ]:
H-9,DiHCl

Chemical & Physical Properties

[ Boiling Point ]:
479.8ºC at 760mmHg

[ Melting Point ]:
250-255ºC (dec)

[ Molecular Formula ]:
C11H13N3O2S

[ Molecular Weight ]:
251.30500

[ Flash Point ]:
243.9ºC

[ Exact Mass ]:
251.07300

[ PSA ]:
93.46000

[ LogP ]:
2.64380

[ Vapour Pressure ]:
2.3E-09mmHg at 25°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NX4897000
CHEMICAL NAME :
5-Isoquinolinesulfonamide, N-(2-aminoethyl)-, monohydrochloride
CAS REGISTRY NUMBER :
116970-50-4
LAST UPDATED :
199312
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C11-H13-N3-O2-S.Cl-H
MOLECULAR WEIGHT :
287.79

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #92-264030
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
190 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #92-264030

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1,2-Ethanediamine
  • Isoquinoline-5-sulfonyl chloride hydrochloride
  • 5-Isoquinolinesulfonic acid

DownStream

Related Compounds

  • 2-bromo-N-(3-cyclopropyl-3-hydroxypropyl)-5-methoxybenzamide
  • 7-methyl-6-oxo-N-((3-phenyl-1,2,4-oxadiazol-5-yl)methyl)-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
  • 5-bromo-2-chloro-N-(3-cyclopropyl-3-hydroxypropyl)benzamide
  • (E)-N-(3-cyclopropyl-3-hydroxypropyl)-3-(3,4,5-trimethoxyphenyl)acrylamide
  • N-(3-cyclopropyl-3-hydroxypropyl)-1-phenylmethanesulfonamide
  • N-(3-cyclopropyl-3-hydroxypropyl)-3-methoxybenzenesulfonamide
  • N-(3-cyclopropyl-3-hydroxypropyl)-4-fluoro-2-methylbenzenesulfonamide
  • 3-chloro-N-(3-cyclopropyl-3-hydroxypropyl)benzenesulfonamide
  • N-(3-cyclopropyl-3-hydroxypropyl)-2-ethoxybenzenesulfonamide
  • N-(3-cyclopropyl-3-hydroxypropyl)-2-methoxy-5-methylbenzenesulfonamide
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