(2Z)-1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-[[(1R)-1-phenylethyl]amino]-4-(2,4,5-trifluorophenyl)-2-buten-1-one

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Names

[ CAS No. ]:
1169707-29-2

[ Name ]:
(2Z)-1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-[[(1R)-1-phenylethyl]amino]-4-(2,4,5-trifluorophenyl)-2-buten-1-one

Chemical & Physical Properties

[ Molecular Formula ]:
C24H21F6N5O

[ Molecular Weight ]:
509.44700

[ Exact Mass ]:
509.16500

[ PSA ]:
63.05000

[ LogP ]:
4.86260

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (R)-(+)-1-Phenylethylamine
  • (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-one
  • 2,4,5-Trifluorophenylacetic acid
  • 5-(1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

DownStream

  • Sitagliptin phosphate monohydrate
  • Sitagliptin

Related Compounds

  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 5,6-dimethyl-2-(1-methyl-1H-imidazol-4-yl)-1H-1,3-benzodiazole
  • DBCO-COONHS ester
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 2-(Heptan-4-yloxy)ethan-1-amine
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4-Chloro-7-nitrothieno[3,2-d]pyrimidine