(2Z)-1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-[[(1R)-1-phenylethyl]amino]-4-(2,4,5-trifluorophenyl)-2-buten-1-one

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Names

[ CAS No. ]:
1169707-29-2

[ Name ]:
(2Z)-1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-[[(1R)-1-phenylethyl]amino]-4-(2,4,5-trifluorophenyl)-2-buten-1-one

Chemical & Physical Properties

[ Molecular Formula ]:
C24H21F6N5O

[ Molecular Weight ]:
509.44700

[ Exact Mass ]:
509.16500

[ PSA ]:
63.05000

[ LogP ]:
4.86260

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (R)-(+)-1-Phenylethylamine
  • (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-one
  • 2,4,5-Trifluorophenylacetic acid
  • 5-(1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

DownStream

  • Sitagliptin phosphate monohydrate
  • Sitagliptin

Related Compounds

  • Tert-butyl 2-(2-methoxy-4,5-dimethylphenyl)piperazine-1-carboxylate
  • tert-butyl 2-[1-(propan-2-yl)-1H-pyrazol-5-yl]piperazine-1-carboxylate
  • 3-(2-{[(Tert-butoxy)carbonyl]amino}pyrimidin-5-yl)-2-methylpropanoic acid
  • methyl 5-(2-amino-1,1-difluoropropan-2-yl)-1-methyl-1H-pyrrole-2-carboxylate
  • 3-(5-Bromo-3-nitropyridin-2-yl)butanoic acid
  • 3,3-Difluoro-3-(2-fluoro-6-nitrophenyl)propanoic acid
  • tert-butyl N-{1-[1-(1-aminocyclopropyl)cyclopropyl]cyclobutyl}carbamate
  • tert-butyl N-[2-amino-1-(2-chloro-4-fluorophenyl)ethyl]carbamate
  • rac-4-{N-ethyl-1-[(3R,5R)-5-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]oxolan-3-yl]formamido}butanoic acid
  • 2-(1-{5-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]oxolane-3-carbonyl}azetidin-3-yl)acetic acid
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