DMXAA (Vadimezan)

Suppliers

Names

[ Name ]:
DMXAA (Vadimezan)

[Synonym ]:
5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic acid
5,6-dimethylxanthenoneacetic acid
(5,6-Dimethyl-9-oxo-9H-xanthen-4-yl)acetic acid
Vadimezan
2-(5,6-Dimethyl-9-oxo-9H-xanthen-4-yl)acetic acid
9H-Xanthene-4-acetic acid, 5,6-dimethyl-9-oxo-
T C666 BO IVJ D1 E1 N1VQ
ASA-404
DMXAA
5,6-Dimethylxanthenone-4-acetic acid

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
520.9±50.0 °C at 760 mmHg

[ Melting Point ]:
264 °C

[ Molecular Formula ]:
C₁₇H₁₄O₄

[ Molecular Weight ]:
282.291

[ Flash Point ]:
197.1±23.6 °C

[ Exact Mass ]:
282.089203

[ PSA ]:
67.51000

[ LogP ]:
3.60

[ Appearance of Characters ]:
solid | light brown

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.633

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: 17 mg/mL, soluble

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H400

[ Precautionary Statements ]:
P273

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;N: Dangerous for the environment;

[ Risk Phrases ]:
R22;R50/53

[ Safety Phrases ]:
60-61

[ RIDADR ]:
UN 3077

[ WGK Germany ]:
3

[ RTECS ]:
ZD5536200

[ HS Code ]:
2932999099

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Proteomic response to 5,6-dimethylxanthenone 4-acetic acid (DMXAA, vadimezan) in human non-small cell lung cancer A549 cells determined by the stable-isotope labeling by amino acids in cell culture (SILAC) approach.

Drug Des. Devel. Ther. 9 , 937-68, (2015)

5,6-Dimethylxanthenone 4-acetic acid (DMXAA), also known as ASA404 and vadimezan, is a potent tumor blood vessel-disrupting agent and cytokine inducer used alone or in combination with other cytotoxic...

Casein kinase II controls TBK1/IRF3 activation in IFN response against viral infection.

J. Immunol. 194 , 4477-88, (2015)

By sensing viral nucleic acids, host innate receptors elicit signaling pathways converging on TBK1-IFN regulatory factor (IRF)3 axis in mediating IFN-αβ induction and defense mechanisms. In contrast, ...

TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN.

Eur. J. Immunol. 45(4) , 1159-69, (2015)

Agonists for TLR9 and Stimulator of IFN Gene (STING) act as vaccine adjuvants that induce type-1 immune responses. However, currently available CpG oligodeoxynucleotide (ODN) (K-type) induces IFNs onl...