Ethanamine,2-[4-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthalenyl)phenoxy]-N,N-diethyl-,hydrochloride (1:1)

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Names

[ CAS No. ]:
1178-99-0

[ Name ]:
Ethanamine,2-[4-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthalenyl)phenoxy]-N,N-diethyl-,hydrochloride (1:1)

Chemical & Physical Properties

[ Density]:
1.091g/cm3

[ Boiling Point ]:
554.3ºC at 760 mmHg

[ Molecular Formula ]:
C29H34ClNO2

[ Molecular Weight ]:
464.03900

[ Flash Point ]:
160.7ºC

[ Exact Mass ]:
463.22800

[ PSA ]:
21.70000

[ LogP ]:
7.12310

[ Vapour Pressure ]:
2.5E-12mmHg at 25°C

[ Index of Refraction ]:
1.587

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YE1660000
CHEMICAL NAME :
Triethylamine, 2-(p-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthyl)pheno xy)-, hydrochloride
CAS REGISTRY NUMBER :
1178-99-0
LAST UPDATED :
198910
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C29-H33-N-O2.Cl-H
MOLECULAR WEIGHT :
464.09
WISWESSER LINE NOTATION :
L66 BUT&J BR DO2N2&2& CR& HO1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
547 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 112,439,1963
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
195 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 112,439,1963 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1240 ug/kg
SEX/DURATION :
female 3-4 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 112,439,1963
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1750 ug/kg
SEX/DURATION :
female 7 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 10,78,1967
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
500 ug/kg
SEX/DURATION :
female 10 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 10,78,1967
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
3500 ug/kg
SEX/DURATION :
female 1 day(s) pre-mating female 1-6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
REFERENCE :
CHINAG Chemistry and Industry (London). (Royal Soc. of Chemistry, Distribution Centre, Blackhorse Rd., Letchworth, Herts SG6 1HN, UK) V.1- 1923- Volume(issue)/page/year: (10),408,1963

Related Compounds

  • 3-(3-Fluorophenyl)-5-(2-methoxy-4-methylpyrimidin-5-yl)-1,2,4-oxadiazole
  • (4-Benzylpiperazin-1-yl)(8-fluoro-4-hydroxyquinolin-3-yl)methanone
  • N-(1H-benzimidazol-6-yl)-2-(4-oxoquinazolin-3(4H)-yl)acetamide
  • (4-hydroxy-8-methoxyquinolin-3-yl)[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]methanone
  • 2-(Octahydro-4H-benzo[b][1,4]thiazin-4-yl)acetic acid
  • 4-(5-fluoro-2-methoxyphenyl)-2-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine
  • (1S)-2-amino-1-(6-chloro-1-methyl-1H-indol-3-yl)ethan-1-ol
  • C19H26ClN7O
  • Methyl 2-bromo-5-fluoro-4-(phenylmethoxy)benzoate
  • (8-Chloro-4-hydroxyquinolin-3-yl){4-[2-(pyridin-2-yl)ethyl]piperazin-1-yl}methanone
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