Protein Tyrosine Phosphatase Substrate Monophosphate

Names

[ Name ]:
Protein Tyrosine Phosphatase Substrate Monophosphate

[Synonym ]:
PTPase Substrate Phosphate [pTyr1146]-Insulin Receptor fragment 1142-1153
PROTEIN TYROSINE PHOSPHATASE SUBSTRATE (MONOPHOSPHORYLATED)

Chemical & Physical Properties

[ Molecular Formula ]:
C₇₂H₁₁₁N₁₉O₃₁P₂

[ Molecular Weight ]:
1800.71000

[ Exact Mass ]:
1799.72000

[ PSA ]:
890.20000

[ LogP ]:
0.77310

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Phosphorylation of synthetic insulin receptor peptides by the insulin receptor kinase and evidence that the preferred sequence containing Tyr-1150 is phosphorylated in vivo.

J. Biol. Chem. 261 , 10000, (1986)

Three peptides were synthesized corresponding to potential autophosphorylation sites of the beta subunit of the human insulin receptor. These were peptide 1150 corresponding to amino acids 1142-1153 o...

Assay of phosphotyrosyl protein phosphatase using synthetic peptide 1142-1153 of the insulin receptor.

FEBS Lett. 237 , 137, (1988)

Synthetic peptide 1142-1153 of the insulin receptor was phosphorylated on tyrosine by the insulin receptor and found to be a potent substrate for dephosphorylation by rat liver particulate and soluble...

Intrinsic kinase activity of the insulin receptor. The intact (alpha 2 beta 2) insulin receptor from rat liver contains a kinase domain with greater intrinsic activity than the intact insulin receptor from human placenta.

J. Biol. Chem. 264 , 602, (1989)

We are interested in developing methods to rigorously characterize the intrinsic enzymatic activity of the insulin receptor. We have previously shown that the intact, kinase active form of the recepto...