Luzindole

Suppliers

Names

[ Name ]:
Luzindole

[Synonym ]:
N-[2-(2-Benzyl-1H-indol-3-yl)ethyl]acetamide
Luzindole
Acetamide, N-[2-[2-(phenylmethyl)-1H-indol-3-yl]ethyl]-
N-Acetyl-2-benzyltryptamine
2-Benzyl-N-acetyltryptamine
N-0774
N-Acetyl-2-benzyltryptamine N-[2-[2-(Phenylmethyl)-1H-indol-3-yl]ethyl]acetamide
MFCD00672498
Arachidonyl serotonin
Tocris-0877

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
559.6±38.0 °C at 760 mmHg

[ Melting Point ]:
44-46°C

[ Molecular Formula ]:
C₁₉H₂₀N₂O

[ Molecular Weight ]:
292.375

[ Flash Point ]:
292.2±26.8 °C

[ Exact Mass ]:
292.157562

[ PSA ]:
44.89000

[ LogP ]:
3.04

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.632

[ Storage condition ]:
−20°C

[ Stability ]:
Store at -20°C

[ Water Solubility ]:
DMSO: 5 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Inhibitory effect of melatonin on testosterone synthesis is mediated via GATA-4/SF-1 transcription factors.

Reprod. Biomed. Online 31 , 638-46, (2015)

The aim of the present study was to elucidate whether the GATA-4/SF-1 signalling pathway is involved in the inhibitory effects of melatonin on testosterone production in both the TM3 Leydig cell line ...

Selective protection of the cerebellum against intracerebroventricular LPS is mediated by local melatonin synthesis.

Brain Struct. Funct. 220(2) , 827-40, (2015)

Although melatonin is mainly produced by the pineal gland, an increasing number of extra-pineal sites of melatonin synthesis have been described. We previously demonstrated the existence of bidirectio...

The influence od melatonin receptors antagonists, luzindole and 4-phenyl-2-propionamidotetralin (4-P-PDOT), on melatonin-dependent vasopressin and adrenocorticotropic hormone (ACTH) release from the rat hypothalamo-hypophysial system. In vitro and in vivo studies.

J. Physiol. Pharmacol. 65(6) , 777-84, (2015)

Melatonin exerts its biological role acting via G protein-coupled membrane receptors - MT1 and MT2, as well as through cytoplasmic and/or nuclear receptors. Melatonin has previously been shown to chan...