1,3,3 TRIMETHYL-2-METHYLENE INDOLINE

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Names

[ CAS No. ]:
118-12-7

[ Name ]:
1,3,3 TRIMETHYL-2-METHYLENE INDOLINE

[Synonym ]:
1,3,3-trimethyl-2-methylideneindole
1,3,3-TriMethyl-2-Methyleneindoline
MFCD00005813
EINECS 204-235-1
Fischer's Base
2-Methylene-1,3,3-trimethylindoline,Fischer base
1,3,3 TRIMETHYL-2-METHYLENE INDOLINE

Chemical & Physical Properties

[ Density]:
0.979 g/mL at 25 °C(lit.)

[ Boiling Point ]:
248 °C(lit.)

[ Melting Point ]:
-8 °C

[ Molecular Formula ]:
C12H15N

[ Molecular Weight ]:
173.25400

[ Flash Point ]:
215 °F

[ Exact Mass ]:
173.12000

[ PSA ]:
3.24000

[ LogP ]:
2.99270

[ Vapour Pressure ]:
0.0249mmHg at 25°C

[ Index of Refraction ]:
n20/D 1.577(lit.)

[ Water Solubility ]:
negligible

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NM1926500
CHEMICAL NAME :
Indoline, 2-methylene-1,3,3-trimethyl-
CAS REGISTRY NUMBER :
118-12-7
BEILSTEIN REFERENCE NO. :
0131162
LAST UPDATED :
199710
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C12-H15-N
MOLECULAR WEIGHT :
173.28
WISWESSER LINE NOTATION :
T56 BNY DHJ B1 CU1 D1 D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#07782 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6185 No. of Facilities: 45 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 775 (estimated) No. of Female Employees: 20 (estimated)

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H400

[ Precautionary Statements ]:
P273

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R38;R50/53

[ Safety Phrases ]:
S28-S60-S61-S57-S37

[ RIDADR ]:
UN 3082 9/PG 3

[ WGK Germany ]:
2

[ RTECS ]:
NM1926500

[ Hazard Class ]:
9.0

[ HS Code ]:
29339990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1,2,3,3-Tetramethyl-3H-indolium iodide
  • 2-(1,3,3-trimethylindol-2-ylidene)acetonitrile
  • spiro-1,3,3-trimethylindoline[2:3']-3',4'-dihydroisoxazole
  • 1-Methylindole
  • methyl iodide
  • 2,3-Dimethyl-1H-indole
  • Indole
  • 3-Methylindole
  • 1,3,3-Trimethyl-2-(formylmethylene)indoline

DownStream

  • (4Z)-3-oxo-4-[(1,3,3-trimethylindol-1-ium-2-yl)methylidene]-2-[(E)-(1,3,3-trimethylindol-2-ylidene)methyl]cyclobuten-1-olate
  • 2,3,3-Trimethyl-2,3-dihydro-1H-indole
  • methyl iodide
  • 6 8-DIBROMO-1' 3'-DIHYDRO-1' 3' 3'-TRI-&
  • 1',3',3'-trimethyl-6,8-dinitrospiro[chromene-2,2'-indole]
  • 1,3-Bis(1,3-dihydro-1,3,3-trimethyl-2H-indol-2-ylidene)-2-propanone
  • 1,3,3-Trimethyl-2-(formylmethylene)indoline
  • 5-Chloro-2-methylene-1,3,3-trimethylindoline
  • 6-chloro-1,3,3-trimethyl-2-methyleneindoline
  • Basic Red 12

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Angew. Chem. Int. Ed. Engl. 66 , 555, (1954)

Ishmetova, R., I.; et al.

Heterocycles 83 , 1363, (2011)

York, M.; Evans, R., A.

Tetrahedron Lett. 51 , 2195, (2010)


More Articles

Related Compounds

  • 1,3,3-trimethyl-2-methylene-5-(trifluoromethyl)indolenine
  • 1,3,3-trimethyl-2-[(phenylazo)methylene]indoline
  • 1,3,3-trimethyl-2-[[(p-tolyl)azo]methylene]indoline
  • 1,3,3-trimethyl-2-methylene-6-nitroindoline
  • 1,3,3-trimethyl-2-methylene-5-indolinecarboxylic acid methyl ester
  • C-(1,3,3-triMethyl-2-Methylene-2,3-dihydro-indole-5-yl)-MethylaMine
  • 2-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[4-(1H-1,2,3-triazol-1-yl)piperidin-1-yl]ethan-1-one
  • 1-(5-methyl-1-phenyl-1H-pyrazole-4-carbonyl)-4-(1H-1,2,3-triazol-1-yl)piperidine
  • N-cyclohexyl-4-(1H-1,2,3-triazol-1-yl)piperidine-1-carboxamide
  • Tert-butyl ((1-((6-chloropyridazin-3-yl)methyl)pyrrolidin-2-yl)methyl)carbamate
  • 4-(1H-1,2,3-triazol-1-yl)-1-((4-(trifluoromethoxy)phenyl)sulfonyl)piperidine
  • 1-((1-methyl-1H-imidazol-4-yl)sulfonyl)-4-(1H-1,2,3-triazol-1-yl)piperidine
  • N-((5-(thiophen-3-yl)pyridin-3-yl)methyl)pyrazine-2-carboxamide
  • 4-methyl-N-((5-(thiophen-3-yl)pyridin-3-yl)methyl)thiophene-2-carboxamide
  • 4-methyl-N-{[5-(thiophen-3-yl)pyridin-3-yl]methyl}-1,2,3-thiadiazole-5-carboxamide
  • N-((5-(thiophen-3-yl)pyridin-3-yl)methyl)cinnamamide
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