3-hydroxyquinoline-4-carboxylic acid

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Names

[ CAS No. ]:
118-13-8

[ Name ]:
3-hydroxyquinoline-4-carboxylic acid

[Synonym ]:
CINCHONINIC ACID,3-HYDROXY
3-hydroxy-quinoline-4-carboxylic acid
3-Hydroxy-4-carboxy-chinolin
3-Hydroxycinchoninic acid
EINECS 204-236-7
3-Hydroxy-chinolin-4-carbonsaeure
3-Hydroxy-4-Quinolinecarboxylicacid

Chemical & Physical Properties

[ Density]:
1.48g/cm3

[ Boiling Point ]:
384.7ºC at 760mmHg

[ Molecular Formula ]:
C10H7NO3

[ Molecular Weight ]:
189.16700

[ Flash Point ]:
186.5ºC

[ Exact Mass ]:
189.04300

[ PSA ]:
70.42000

[ LogP ]:
1.63860

[ Vapour Pressure ]:
1.32E-06mmHg at 25°C

[ Index of Refraction ]:
1.73

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GD3870000
CHEMICAL NAME :
Cinchoninic acid, 3-hydroxy-
CAS REGISTRY NUMBER :
118-13-8
BEILSTEIN REFERENCE NO. :
0154787
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C10-H7-N-O3
MOLECULAR WEIGHT :
189.18
WISWESSER LINE NOTATION :
T66 BNJ DVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JHHBAI Bulletin of the Johns Hopkins Hospital. (Baltimore, MD) V.1-119, 1889-1966. For publisher information, see JHMJAX. Volume(issue)/page/year: 88,181,1951

Safety Information

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3-hydroxyquinoline-4-carbonitrile
  • isatin
  • 3-CHLOROPYRUVIC ACID
  • 4-Cyanoquinoline
  • 1-oxidoquinolin-1-ium-4-carbonitrile
  • 3-Aminoquinoline-4-carboxylic acid

DownStream

  • 4-Quinolinecarboxylicacid,3-hydroxy-,methylester(9CI)

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 2-ethyl-3-hydroxyquinoline-4-carboxylic acid
  • 6-bromo-3-hydroxyquinoline-4-carboxylic acid
  • 7-bromo-3-hydroxyquinoline-4-carboxylic acid
  • 5-bromo-3-hydroxyquinoline-4-carboxylic acid
  • 2-Chloro-3-hydroxyquinoline-4-carboxylic acid
  • 2-(2-chlorophenyl)-3-hydroxyquinoline-4-carboxylic acid
  • 3-(4-Chloro-3-methylphenyl)pyrrolidine
  • 3-Hydroxy-1-phenyl-2-pyrrolidinone
  • Tert-butyl 3-(3,5-dichlorophenyl)pyrrolidine-1-carboxylate
  • Tert-butyl 3-(4-chloro-3-methylphenyl)pyrrolidine-1-carboxylate
  • Tert-butyl 4-(3,5-dichlorophenyl)-2-methoxypyrrolidine-1-carboxylate
  • (5-Bromomethyloxazol-2-yl)cyclohexylphenylmethanol
  • Cyclohexyl-(5-dimethylaminomethyl-oxazol-2-yl)phenylmethanol
  • (5-Methyloxazol-2-yl)phenylmethanone
  • 2-Oxo-2,3-dihydrobenzo[d]thiazole-5-carboxylic acid
  • 3-(4-fluoro-1H-indol-7-yl)-1,2,4-oxadiazole